Clinical and Translational Oncology

, Volume 16, Issue 2, pp 220–223 | Cite as

Tackling gliomas with nanoformulated antineoplastic drugs: suitability of hyaluronic acid nanoparticles

  • M. Ganau


The development of drug delivery systems able to induce accumulation of a prodrug or its metabolites in aggressive tumours is providing new approaches to achieve enhanced antitumor activity while reducing systemic toxicity. Only recently, the integration of core concepts from the field of biotechnology, nanotechnology and pharmacodynamics provided us with new insights on the possibility to identify anti-neoplastic targets and evaluate the theoretical feasibility of producing drug-incorporated hyaluronic acid (HA)-nanoparticles. Indeed, gliomas could represent the perfect proof of concept for nanoformulated drugs due to the intrinsic characteristics of those tumours: mainly, the high aggressiveness, poor prognosis and high degree of chemo-resistance. A thorough analysis of the current therapeutic armamentarium available for primary brain tumours, and the possible targets of HA-nanoparticles, is perfectly suited to better understand the opportunities provided by such...


Hyaluronic Acid Glioma Cell Malignant Glioma Primary Brain Tumour Glioma Invasion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We are grateful to Mrs Gloria Mognon for revision of the language and editing of the manuscript in its final version.

Conflict of interest

The author does not report any financial, personal or professional conflict of interest concerning the materials and methods used in this study or the findings specified in this paper.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2013

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringUniversity of CagliariCagliariItaly

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