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Clinical and Translational Oncology

, Volume 14, Issue 12, pp 891–895 | Cite as

Role of gamma-delta T-cells in cancer. Another opening door to immunotherapy

  • Diego Marquez-Medina
  • Joel Salla-Fortuny
  • Antonieta Salud-Salvia
Educational Series – Red Series* NEW TRENDS IN CLINICAL ONCOLOGY

Abstract

The gamma-delta (γδ) T-cells are a subset of T-lymphocytes characterized by the presence of a surface antigen recognition complex type 2. Those γδ T-cells represent 2–5 % of peripheral T-cells only, but they are common in organs and mucosae, acting as a first defense system in the entries to the organism. The γδ T-cells take part on immune response by direct cytolysis, development of memory phenotypes, and modulation of immune cells, and they have been implied in autoimmune disorders, immune deficiencies, infections, and tumor diseases. We reported the role of γδ T-cells in oncology, focusing in their potential applications for cancer treatment. Experimental designs and clinical trials in the treatment of solid malignancies are extensively reviewed.

Keywords

Gamma-delta T-cells Immune therapy Non-small cell lung cancer Solid malignancies Zoledronic acid 

Notes

Conflict of interest

Authors did not have any conflict of interest in the redaction of this manuscript.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2012

Authors and Affiliations

  • Diego Marquez-Medina
    • 1
  • Joel Salla-Fortuny
    • 1
  • Antonieta Salud-Salvia
    • 1
  1. 1.Medical Oncology DepartmentUniversity Hospital Arnau de VilanovaLleidaSpain

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