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Clinical and Translational Oncology

, Volume 14, Issue 11, pp 842–847 | Cite as

Predicting the factors of lateral lymph node metastasis in papillary microcarcinoma of the thyroid in eastern China

  • Rui-chao Zeng
  • Quan LiEmail author
  • Kuai-lu Lin
  • Wei Zhang
  • Er-li Gao
  • Guan-li Huang
  • Xiao-hua Zhang
  • Min-hua Zheng
Research Article

Abstract

Introduction

Lateral lymph node metastasis is common in papillary thyroid microcarcinoma (PTMC). The present study evaluated the clinicopathologic characteristics and ultrasonographic (US) findings in predicting lateral LNM from PTMC in eastern China.

Materials and methods

A total of 176 patients with confirmed PTMC by final histological examination who underwent central lymph node dissection (LND) and lateral LND were enrolled in our study. The clinicopathological and US data from the cases were analyzed retrospectively to determine the independent predictive factors for lateral LNM. Then, a scoring system was developed on the basis of independent factors. The sum of the points for individuals was evaluated for the value in predicting lateral LNM.

Results

Central LNM, underlying Hashimoto’s thyroiditis, upper pole location, no well-defined margin and presence of calcifications were independent predictive factors for lateral LNM on multivariate analysis. Clinicopathological and US index points were statistically significant, with ≤2 favoring lateral LNM negativity with a sensitivity of 83.3 %, positive predictive value of 89.6 % and negative predictive value of 72.9 %.

Conclusions

When the evaluation for lateral lymph nodes from a preoperative approach is inadequate or not obvious, our scoring system for prediction of lateral LNM can be another choice. Patients with clinicopathological and US index points ≤2 could be considered as lateral LNM negative, so more diagnostic approach is recommended for patients with clinicopathological and US index points >2.

Keywords

Thyroid neoplasms Papillary thyroid microcarcinoma Ultrasonographic Lateral lymph node metastasis 

Abbreviations

LNM

Lymph node metastasis

PTMC

Papillary thyroid microcarcinoma

PTC

Papillary thyroid carcinoma

ROC curves

Receiver-operating characteristic curves

US

Ultrasonographic

FNAC

Fine-needle aspiration cytology

LND

Lymph node dissection

Notes

Conflict of interest

There is no financial relationship that might lead to a conflict of interest in relation to the manuscript.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2012

Authors and Affiliations

  • Rui-chao Zeng
    • 1
  • Quan Li
    • 1
    Email author
  • Kuai-lu Lin
    • 1
  • Wei Zhang
    • 1
  • Er-li Gao
    • 1
  • Guan-li Huang
    • 1
  • Xiao-hua Zhang
    • 1
  • Min-hua Zheng
    • 2
  1. 1.Department of OncologyThe First Affiliated Hospital of Wenzhou Medical CollegeWenzhouPeople’s Republic of China
  2. 2.Department of RadiologyThe First Affiliated Hospital of Wenzhou Medical CollegeWenzhouPeople’s Republic of China

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