Clinical and Translational Oncology

, Volume 14, Issue 3, pp 169–176 | Cite as

Castration-resistant metastatic prostate cancer: current status and treatment possibilities

  • Joan Carles
  • Daniel Castellano
  • Miguel Ángel Climent
  • Pablo Maroto
  • Rafael Medina
  • Antonio Alcaraz
Educational Series / Red Series New Trends in Clinical Oncology


Prostate cancer (PCa) is the most common cancer in the male population in Western countries, second to skin cancer. Hormonal therapy allows long-lasting and effective control of cancer-related symptoms in advanced stages; however, in almost all patients with metastatic PCa the disease will progress when it becomes castration-resistant (CRPC). Chemotherapy with docetaxel was a turning point in CRPC, as, for the first time, it resulted in an increased survival time in comparison with mitoxantrone and prednisone. Combination therapy with docetaxel and prednisone is the first-line treatment of choice. Once the cancer has progressed, there is no clear alternative, although some new agents have shown promise in the treatment of this type of cancer. This review will provide an overview of the current status of CRPC, including clinical status, prognosis, firstline treatment and new second-line treatment options.


Metastatic prostate cancer Castration-resistant prostate cancer Hormonal therapies Progression Cabazitaxel 


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Copyright information

© Feseo 2012

Authors and Affiliations

  • Joan Carles
    • 1
    • 7
  • Daniel Castellano
    • 2
  • Miguel Ángel Climent
    • 3
  • Pablo Maroto
    • 4
  • Rafael Medina
    • 5
  • Antonio Alcaraz
    • 6
  1. 1.Servicio de OncologíaInstituto de Oncología de la Vall d’HebronBarcelonaSpain
  2. 2.Servicio de OncologíaHospital Universitario 12 de OctubreMadridSpain
  3. 3.Servicio de OncologíaInstituto Valenciano de OncologíaValenciaSpain
  4. 4.Servicio de OncologíaHospital de Sant PauBarcelonaSpain
  5. 5.Servicio de UrologíaHospital Universitario Virgen del RocíoSevillaSpain
  6. 6.Servicio de Urología IDIBAPSHospital Clínic de BarcelonaBarcelonaSpain
  7. 7.Departamento de OncologíaHospital General Vall d’HebronBarcelonaSpain

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