The EORTC quality of life questionnaire for patients with colorectal cancer: EORTC QLQ-CR29 validation study for Spanish patients
The EORTC Quality of Life (QL) Group has developed a questionnaire -the EORTC QLQ-CR29- for evaluating QL in colorectal cancer. The aim of this study is to assess the psychometric properties of the EORTC QLQ-CR29 when applied to a sample of Spanish patients.
Materials and methods
Eighty-four locally advanced rectal cancer patients in the treatment follow-up period after receiving surgery and neoadjuvant chemoradiotherapy were included in the study. Seventy subjects also had adjuvant chemotherapy. Patients completed both the EORTC QLQ-C30 and the QLQ-CR29 once. The psychometric evaluation of the questionnaire’s structure, reliability, and convergent, divergent and known-groups validity was performed.
Multitrait scaling analysis showed that three of the multi-item scales met the standards of convergent and discriminant validity. These same scales reached the 0.7 Cronbach’s coefficient criterion or were close to it. In both analyses exceptions were observed in the blood and mucus in stool scale. Correlations between the scales of the QLQ-C30 and the module were low (r<0.02) in most cases. A few areas with more related content had higher correlations (r<0.05). Group comparison analyses showed differences in QL between groups of patients based on age, comorbidity, performance status, receipt of adjuvant chemotherapy and surgery modality.
The EORTC QLQ-CR29 is a reliable and valid instrument when applied to a sample of Spanish rectal cancer patients. These results are in line with those of the EORTC validation study.
KeywordsCancer Colorectal Quality of life Validation Spanish Questionnaire
Unable to display preview. Download preview PDF.
- 1.Ferlay J, Bray F, Pisani P, Parkin DM (2004) GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide. IARC CancerBase N°5, version 2.0. IARC Press, LyonGoogle Scholar
- 2.Libutti S, Saltz L, Tepper J (2008) Colon cancer. In: De Vita V, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 8th edn. Lippincott, Williams and Wilkins, Philadelphia, pp 1232–1277Google Scholar
- 3.Libutti S, Tepper J, Saltz L (2008) Rectal cancer. In: De Vita V, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 8th edn. Lippincott, Williams and Wilkins, Philadelphia, pp 1285–1298Google Scholar
- 4.American Society of Clinical Oncology (1996) Outcomes of cancer treatment for technology assessment and cancer treatment guidelines. J Clin Oncol 14:671–679Google Scholar
- 6.Aaronson NK, Cull A, Kaasa S et al (1994) The EORTC modular approach to Quality of Life assessment in oncology. Int J Ment Health 23:75–96Google Scholar
- 8.Arraras JI, Vera R, Manterota A et al (2003) El cuestionario de Calidad de Vida para cáncer colorectal EORTC QLQ-CR38. Estudio de validación para nuestro país. Oncología 26:285–292Google Scholar
- 15.Arraras JI, Villafranca E, Arias F et al (2008) The EORTC Quality of life questionnaire QLQ-C30 (version 3.0). Validation study for Spanish prostate cancer patients. Arch Esp Urol 61:949–954Google Scholar
- 16.Cull A, Sprangers M, Bjordal K et al (2002) EORTC Quality of Life Group translation procedure, 2nd edn. EORTC, BrusselsGoogle Scholar
- 17.Karnofsky DA, Burchenal JH (1948) The clinical evaluation of chemotherapeutic agents in cancer. In: McLeod CM (ed.) Evaluation of chemotherapeutic agents. Colombia University, New York, pp 199–205Google Scholar
- 18.Ware JE, Harris WJ, Gandek B et al (1997) MAP-R for Windows: Multitrait Multi-Item Analysis Program-revised user’s guide. Health Assessment Lab, BostonGoogle Scholar