Clinical and Translational Oncology

, Volume 12, Issue 6, pp 443–449 | Cite as

Expression of EGFR, HER-2/neu and KIT in germ cell tumours

  • Ignacio Durán
  • Adelaida García-Velasco
  • Claudio Ballestín
  • Elena García
  • Francisco Martínez-Tello
  • Gregory R. Pond
  • Rocío García-Carbonero
  • Hernán Cortés-Funés
  • Luis Paz-Ares
Research Articles

Abstract

Background

Germ cell tumours (GCTs) represent an extraordinarily chemosensitive malignancy. However, 20–30% of patients with advanced disease cannot be cured by currently available treatments. The role of tyrosine kinase receptors has been widely studied in other malignancies. Yet, limited information is available on GCTs.

Methods

One hundred and nine paraffin-embedded GCTs in 84 patients were assessed by immunohistochemistry for epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER-2)/neu and KIT (CD117) expression. Univariate and multivariate analyses were performed to evaluate their role as predictive and/or prognostic factors.

Results

EGFR and HER-2/neu staining was detected in 28% and 13% of tumours, respectively, predominantly in nonseminomatous GCTs. KIT protein was almost universally expressed in seminomas (97%), being virtually absent in choriocarcinoma and teratocarcinoma subtypes. EGFR expression showed inverse association with tumour response of borderline significance. With a median follow-up of 10.6 years, no significant association was observed between the expression of any of these markers and relapsefree or overall survival.

Conclusions

EGFR, HER-2/neu and KIT have differential patterns of expression in GCTs according to histological subtypes. The expression of these markers in our series had no prognostic or predictive significance.

Keywords

EGFR KIT HER-2/neu Germ cell tumours 

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Copyright information

© Feseo 2010

Authors and Affiliations

  • Ignacio Durán
    • 1
    • 5
  • Adelaida García-Velasco
    • 1
  • Claudio Ballestín
    • 2
  • Elena García
    • 2
  • Francisco Martínez-Tello
    • 2
  • Gregory R. Pond
    • 3
  • Rocío García-Carbonero
    • 4
  • Hernán Cortés-Funés
    • 1
  • Luis Paz-Ares
    • 1
  1. 1.Medical Oncology DepartmentHospital Universitario Doce de OctubreMadridSpain
  2. 2.Pathology DepartmentHospital Universitario Doce de OctubreMadridSpain
  3. 3.Biostatistics Department Princess Margaret HospitalUniversity Health NetworkTorontoCanada
  4. 4.Medical Oncology DepartmentHospital Severo Ochoa LeganésMadridSpain
  5. 5.Centro Integral Oncológico Clara CampalMadridSpain

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