Clinical and Translational Oncology

, Volume 12, Issue 3, pp 234–237 | Cite as

Biliary cystadenocarcinoma with mesenchymal stroma

  • Carlos Gómez-MartínEmail author
  • Analia Rodríguez
  • Diego Malón
  • Hernán Cortés-Funes
Case Reports


Hepatobiliary cystadenocarcinomas (BCACs) with mesenchymal stroma are a rare cystic lesion. This tumour needs to be distinguished from benign biliary cystadenoma, which is antecedent in most cases. The treatment of choice is radical excision of the mass. The diagnostic evaluation, surgical management, pathological characteristics, treatment and follow-up of one patient with hepatobiliary cystadenocarcinoma with ovarian stroma is described. Preoperative diagnosis of BCACs is often difficult, because their clinical manifestations are similar to those of other hepatic cystic lesions. MRI is suitable for accurate characterisation of cystic biliary lesions, but distinguishing between cystadenoma and cystadenocarcinoma remains difficult on the basis of imaging findings. Complete surgical excision gives a relatively good chance of long-term survival because of the slow growth rate of these tumours.


Hepatic cystic tumours Biliary cystadenocarcinoma Liver neoplasms 


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  1. 1.
    Ttsiftsis D, Christodoulakis M, de Bree E, Sanidas E (1997) Primary intrahepatic biliary cystadenomatous tumors. J Surg Oncol 64:341–346CrossRefGoogle Scholar
  2. 2.
    Erdogan D, Busch ORC, Rauws EAJ et al (2006) Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma. World J Gastroenterol 12:5735–5738PubMedGoogle Scholar
  3. 3.
    Del Poggio P, Buonocore M (2008) Cystic tumors of the liver: a practical approach. World J Gastroenterol 14:3616–3620CrossRefPubMedGoogle Scholar
  4. 4.
    Waldmann J, Zielke A, Moll R et al (2006) Cystadenocarcinoma of the gallbladder. J Hepatobiliary Pancreat Surg 13:594–599CrossRefPubMedGoogle Scholar
  5. 5.
    Buetow PC, Buck JL, Pantongrag-Brown L et al (1995) Biliary cystadenoma and cystadenocarcinoma: clinical-imaging-pathologic correlation with emphasis on the importance of ovarian stroma. Radiology 196:805–810PubMedGoogle Scholar
  6. 6.
    Devaney K, Goodman ZD, Ishak KG (1994) Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol 18:1078–1091PubMedCrossRefGoogle Scholar
  7. 7.
    Zen Y, Fujii T, Itatsu K et al (2006) Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct. Mod Pathol 19:1243–1254CrossRefPubMedGoogle Scholar
  8. 8.
    Lewin M, Mourra N, Honigman I et al (2006) Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma. Eur Radiol 16:407–413CrossRefPubMedGoogle Scholar
  9. 9.
    Yu Q, Chen T, Wan YL et al (2009) Intrahepatic biliary cystadenocarcinoma: clinical analysis of 4 cases. Hepatobiliary Pancreat Dis Int 8: 71–74PubMedGoogle Scholar
  10. 10.
    Thomas JA, Scriven MW, Puntis MC et al (1997) Elevated serum CA 19-9 levels in hepatobiliary cystadenoma with mesenchymal stroma. Two case reports with immunohistochemical confirmation. Cancer 70:1841–1846Google Scholar
  11. 11.
    O’Grady JG (2000) Treatment options for other hepatic malignancies. Liver Transpl 6[Suppl 2]:S23–S29CrossRefPubMedGoogle Scholar

Copyright information

© Feseo 2010

Authors and Affiliations

  • Carlos Gómez-Martín
    • 1
    Email author
  • Analia Rodríguez
    • 1
  • Diego Malón
    • 1
  • Hernán Cortés-Funes
    • 1
  1. 1.Medical Oncology Division Gastrointestinal Cancer Unit12 Octubre University HospitalMadridSpain

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