Sarcoidosis as a diagnostic pitfall of pancreatic cancer

  • Francisco Zambrana
  • Alejandro Antúnez
  • Jesús García-Mata
  • José M. Mellado
  • José L. Villar
Case Reports

Abstract

Sarcoidosis (SA) is accompanied by malignancy more than can be explained by chance. Cancer can occur in patients with an established diagnosis of SA and SA can subsequently develop in a cancer patient. Malignancy can also be associated with the occurrence of sarcoid reactions (SR), which are typically restricted to the regional lymph nodes. Problems may also arise in distinguishing between tumour-related SRs and true systemic SA. Here we present a case with both SA and pancreatic cancer, and we discuss the result of distinguishing between SA and SRs in a patient with concurrent cancer.

Keywords

Sarcoidosis malignancy Sarcoid-like reaction Neoplasm 

References

  1. 1.
    Brincker H, Wilbek E (1974) The incidence of malignant tumors in patients with sarcoidosis. Br J Cancer 29:247–251PubMedGoogle Scholar
  2. 2.
    Reich JM, Mullooly JP, Johnson RE (1995) Linkage analysis of malignancy-associated sarcoidosis. Chest 107:605–613PubMedCrossRefGoogle Scholar
  3. 3.
    Romer FK, Hommelgaard P, Schou G (1998) Sarcoidosis and cancer revisited: a long-term followup study of 555 Danish sarcoidosis patients. Eur Respir J 12:906–912PubMedCrossRefGoogle Scholar
  4. 4.
    Askling J, Grunewald J, Eklund A et al (1999) Increased risk for cancer following sarcoidosis. Am J Respir Crit Care Med 160:1668–1672PubMedGoogle Scholar
  5. 5.
    Mao JT, Fishbein MC (2000) Metastatic pancreatic cancer masquerading as pulmonary sarcoidosis. Am J Med 109:598–599PubMedCrossRefGoogle Scholar
  6. 6.
    Saunders J (1976) Lymph node and hepatic granulomata associated with carcinoma. Br Med J 1:437–438PubMedCrossRefGoogle Scholar
  7. 7.
    Brincker H (1986) Sarcoid reaction in malignant tumors. Cancer Treat Rev 13:147–156PubMedCrossRefGoogle Scholar
  8. 8.
    Brincker H, Pedersen NT (1991) Immunohistologic separation of B-cell-positive granulomas from B-cell-negative granulomas in paraffin-embedded tissue with special reference to tumor-related sarcoid reactions. APMIS 99:282–290PubMedCrossRefGoogle Scholar
  9. 9.
    Boros DL (1983) Experimental granulomatous disease. In: Fanberg BL (ed.) Sarcoidosis and other granulomatous diseases of the lung. Marcel Dekker, New York, pp 403–449Google Scholar
  10. 10.
    Brincker H (1992) Interpretation of granulomatous lesion in malignancy. Acta Oncol 6:85–89CrossRefGoogle Scholar
  11. 11.
    Trump KL, Ettinger DS, Feldman JM et al (1981) Sarcoidosis and sarcoid-like lesions: their occurrence after cytotoxic and radiation therapy of testis cancer. Arch Intern Med 141:37–38PubMedCrossRefGoogle Scholar

Copyright information

© Feseo 2009

Authors and Affiliations

  • Francisco Zambrana
    • 1
  • Alejandro Antúnez
    • 2
  • Jesús García-Mata
    • 3
  • José M. Mellado
    • 3
  • José L. Villar
    • 2
  1. 1.Department of Medical OncologyHospital Universitario Virgen MacarenaSevillaSpain
  2. 2.Department of PathologyHospital Universitario Virgen MacarenaSevillaSpain
  3. 3.Department of MedicineHospital Universitario Virgen MacarenaSevillaSpain

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