Hedgehog signalling as a target in cancer stem cells
- 179 Downloads
Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh plays a central role in the proliferative control and differentiation of both embryonic stem cells and adult stem cells. In this way, an alteration in the Hh pathway, either by misexpression of components of that pathway or by changes in the expression of other cellular components that interfere with the Hh signalling system, may trigger the development of several types of cancer. This occurs because normal stem cells or their intermediaries toward differentiated mature cells are not part of the normal proliferative/differentiation balance and begin to expand without control, triggering the generation of the so-called cancer stem cells. In this review, we will focus on the molecular aspects and the role of Hh signalling in normal tissues and in tumour development.
KeywordsHh (Hedgehog) Smoothened (Smo) Patched (Ptc) Gli Cancer Cancer stem cells
Unable to display preview. Download preview PDF.
- 2.Gunbin KV, Omelyanchuk LV, Ananko EA (2004) Two gene networks underlying the formation of the anterior-posterior and dorso-ventral wing imaginal disc compartment boundaries in Drosophila melanogaster. In: Kolchanov NA and Hofestaedt R (eds) Proceedings of the Fourth International Conference on Bioinformatics of Genome Regulation and Structure, BGRS’2004. Institute of Cytology and Genetics Press, Vol. 2, pp 56–59Google Scholar