Clinical and Translational Oncology

, Volume 10, Issue 12, pp 786–793 | Cite as

An update on the biology of cancer stem cells in breast cancer

  • José María García Bueno
  • Alberto Ocaña
  • Paola Castro-García
  • Carmen Gil Gas
  • Francisco Sánchez-Sánchez
  • Enrique Poblet
  • Rosario Serrano
  • Raúl Calero
  • Carmen Ramírez-Castillejo
Educational Series

Abstract

Breast cancer stem cells are defined as cancer cells with self-renewal capacity. These cells represent a small subpopulation endowed with the ability to form new tumours when injected in nude mice. Markers of differentiation have been used to identify these cancer cells. In the case of breast cancer, CD44+/CD24− select a population with stem cell properties. The fact that these cells have self-renewal ability has suggested that this population could be responsible for new tumour formation and cancer relapse. These cells have been shown to be more resistant to chemotherapy and radiotherapy than normal cancer cells. The identification of the molecular druggable alterations responsible for the initiation and maintenance of cancer stem cells is an important goal. In this article we will review all these points with special emphasis on the possible role of new drugs designed to interact with molecular pathways of cancer stem cells.

Keywords

Breast cancer Cancer Stem Cell Cancer ABC transporters Target therapies PEDF Notch Wnt Hedgehog 

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Copyright information

© Feseo 2008

Authors and Affiliations

  • José María García Bueno
    • 1
    • 2
  • Alberto Ocaña
    • 1
    • 2
  • Paola Castro-García
    • 1
    • 5
  • Carmen Gil Gas
    • 1
    • 5
  • Francisco Sánchez-Sánchez
    • 4
  • Enrique Poblet
    • 1
    • 3
  • Rosario Serrano
    • 1
  • Raúl Calero
    • 1
  • Carmen Ramírez-Castillejo
    • 1
    • 5
  1. 1.Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La ManchaAlbaceteSpain
  2. 2.Unidad de OncologíaCHUAAlbaceteSpain
  3. 3.Unidad de Anatomía PatológicaCHUAAlbaceteSpain
  4. 4.Área de Genética Facultad de Medicina/CRIBAlbaceteSpain
  5. 5.Laboratorio de Células Madre/CRIBUniversidad de Castilla-La ManchaCastillaSpain

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