Clinical and Translational Oncology

, Volume 10, Issue 4, pp 189–197 | Cite as

Genetic changes in small cell lung carcinoma

  • Edurne Arriola
  • Israel Cañadas
  • Montse Arumí
  • Federico Rojo
  • Ana Rovira
  • Joan Albanell
Educational Series


Small cell lung carcinoma (SCLC) accounts for approximately 15% of all lung cancer cases. Despite a frequently good response to first-line treatment with chemotherapy and/or radiotherapy, early relapse occurs in the majority of patients and 5-year survival is only about 5%. Therefore, there is a need to develop novel treatments to improve the outcome of patients with SCLC. To fulfil this need, it is critical to gain further understanding on the molecular basis of SCLC and specifically to identify novel therapeutic targets. Clinical trials with molecularly targeted agents have been performed with little success in the past, but recently many promising oncogenic pathways have been discovered and novel targeted therapies are under evaluation. In this review, we summarise the most relevant genetic and signalling pathway alterations reported to date in SCLC and discuss the potential therapeutic implications of such events.


Small cell lung carcinoma Genetic changes Expression profiles Oncogenic pathways 


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Copyright information

© Feseo 2008

Authors and Affiliations

  • Edurne Arriola
    • 1
    • 2
  • Israel Cañadas
    • 1
    • 2
  • Montse Arumí
    • 2
    • 3
  • Federico Rojo
    • 2
    • 4
  • Ana Rovira
    • 1
    • 2
  • Joan Albanell
    • 1
    • 2
  1. 1.Medical Oncology ServiceHospital del MarBarcelonaSpain
  2. 2.Cancer Research ProgramIMIM-Hospital del MarBarcelonaSpain
  3. 3.Pathology ServiceHospital del MarBarcelonaSpain
  4. 4.Pathology ServiceFundación Jiménez DíazMadridSpain

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