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Indian Journal of Microbiology

, Volume 59, Issue 1, pp 3–12 | Cite as

Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms

  • Priti SaxenaEmail author
  • Yogesh Joshi
  • Kartik Rawat
  • Renu Bisht
Review Article
  • 348 Downloads

Abstract

Biofilm is a mode of living employed by many pathogenic and environmental microbes to proliferate as multicellular aggregates on inert inanimate or biological substrates. Several microbial diseases are associated with biofilms that pose challenges in treatment with antibiotics targeting individual cells. Bacteria in biofilms secrete exopolymeric substances that contribute to architectural stability and provide a secure niche to inhabiting cells. Quorum sensing (QS) plays essential roles in biofilm development. Pathogenic bacteria in biofilms utilize QS mechanisms to activate virulence and develop antibiotic resistance. This review is a brief overview of biofilm research and provides updates on recent understandings on biofilm development, antibiotic resistance and transmission, and importance of QS mechanisms. Strategies to combat biofilm associated diseases including anti-biofilm substances, quorum quenching molecules, bio-surfactants and competitive inhibitors are briefly discussed. The review concludes with updates on recent approaches utilized for biofilm inhibition and provides perspectives for further research in the field.

Keywords

Biofilms eDNA Antibiotic resistance Quorum sensing Quorum quenching 

Notes

Acknowledgements

PS gratefully acknowledges Innovative Young Biotechnologist Award (IYBA) of Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India and South Asian University (SAU) Startup Research Grant, SAU, India for providing funds and support for this study.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Association of Microbiologists of India 2018

Authors and Affiliations

  1. 1.Faculty of Life Sciences and BiotechnologySouth Asian UniversityNew DelhiIndia

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