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Indian Journal of Microbiology

, Volume 55, Issue 4, pp 349–356 | Cite as

Plausible Drug Targets in the Streptococcus mutans Quorum Sensing Pathways to Combat Dental Biofilms and Associated Risks

  • Gurmeet Kaur
  • Shrinidhi Rajesh
  • S. Adline PrincyEmail author
Review Article

Abstract

Streptococcus mutans, a Gram positive facultative anaerobe, is one among the approximately seven hundred bacterial species to exist in human buccal cavity and cause dental caries. Quorum sensing (QS) is a cell-density dependent communication process that respond to the inter/intra-species signals and elicit responses to show behavioral changes in the bacteria to an aggressive forms. In accordance to this phenomenon, the S. mutans also harbors a Competing Stimulating Peptide (CSP)-mediated quorum sensing, ComCDE (Two-component regulatory system) to regulate several virulence-associated traits that includes the formation of the oral biofilm (dental plaque), genetic competence and acidogenicity. The QS-mediated response of S. mutans adherence on tooth surface (dental plaque) imparts antibiotic resistance to the bacterium and further progresses to lead a chronic state, known as periodontitis. In recent years, the oral streptococci, S. mutans are not only recognized for its cariogenic potential but also well known to worsen the infective endocarditis due to its inherent ability to colonize and form biofilm on heart valves. The review significantly appreciate the increasing complexity of the CSP-mediated quorum-sensing pathway with a special emphasis to identify the plausible drug targets within the system for the development of anti-quorum drugs to control biofilm formation and associated risks.

Keywords

Streptococcus mutans Dental biofilms Quorum Sensing CSP ComA Multi-drug resistance 

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Copyright information

© Association of Microbiologists of India 2015

Authors and Affiliations

  • Gurmeet Kaur
    • 1
  • Shrinidhi Rajesh
    • 1
  • S. Adline Princy
    • 1
    Email author
  1. 1.Quorum Sensing Laboratory, Centre for Research on Infectious Diseases (CRID), School of Chemical and BiotechnologySASTRA UniversityThanjavurIndia

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