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Indian Journal of Microbiology

, Volume 54, Issue 1, pp 114–117 | Cite as

Azithromycin Reduces the Production of α-hemolysin and Biofilm Formation in Staphylococcus aureus

  • Zhihong Gui
  • Huafu Wang
  • Ting Ding
  • Wei Zhu
  • Xiyi Zhuang
  • Weihua ChuEmail author
Short Communication

Abstract

Staphylococcus aureus causes a broad range of life-threatening diseases in humans. This bacterium produces a large number of extracellular virulence factors that are closely associated with specific diseases which are controlled by quorum sensing. In this study, we show that azithromycin was active against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranged from 32 to 64 μg/mL. Azithromycin at subinhibitory concentration, markedly reduced the production of α-hemolysin at (1/16MIC, 1/8MIC) and biofilm formation at (1/16MIC, 1/8MIC), respectively. The results indicated that sub-inhibitory concentrations of azithromycin decreased the production of α-hemolysin and biofilm formation in MRSA in a dose-dependent manner. Therefore, azithromycin may be useful in the treatment of α-hemolysin producing and biofilm formation MRSA infections.

Keywords

Staphylococcus aureus Azithromycin Biofilm α-hemolysin 

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Copyright information

© Association of Microbiologists of India 2013

Authors and Affiliations

  • Zhihong Gui
    • 1
  • Huafu Wang
    • 1
  • Ting Ding
    • 1
  • Wei Zhu
    • 2
  • Xiyi Zhuang
    • 2
  • Weihua Chu
    • 2
    Email author
  1. 1.Lishui People’s HospitalLishuiChina
  2. 2.Department of Microbiology, School of Life Science and TechnologyChina Pharmaceutical UniversityNanjingChina

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