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A network map of netrin receptor UNC5B-mediated signaling

  • Sameer Ahmed Bhat
  • Sumrati Gurtoo
  • Sayali Chandrashekhar Deolankar
  • Khalid Majid Fazili
  • Jayshree Advani
  • Rohan Shetty
  • T. S. Keshava Prasad
  • Shaida Andrabi
  • Yashwanth Subbannayya
Nuts and Bolts
  • 149 Downloads

Abstract

UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. This family of receptors can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, where it induces cell death in the absence of its ligand Netrin-1 and promotes cell survival in its presence. In addition, inhibition of Netrin-1 ligand has been reported to decrease invasiveness and angiogenesis in tumors. UNC5B signaling pathway has also been reported to be involved in several processes such as neural development, developmental angiogenesis and inflammatory processes. However, literature pertaining to UNC5B signaling is scarce and scattered. Considering the importance of UNC5B signaling, we developed a resource of signaling events mediated by UNC5B. Using data mined from published literature, we compiled an integrated pathway map consisting of 88 UNC5B-mediated signaling events and 55 proteins. These signaling events include 27 protein-protein interaction events, 33 catalytic events involving various post-translational modifications, 9 events of UNC5B-mediated protein activation/inhibition, 27 gene regulation events and 2 events of translocation. This pathway resource has been made available to the research community through NetPath (http://www.netpath.org/), a manually curated resource of signaling pathways (Database URL: http://www.netpath.org/pathways?path_id=NetPath_172). The current resource provides a foundation for the understanding of UNC5B-mediated cellular responses. The development of resource will serve researchers to explore the mechanisms of UNC-5B signaling in cancers.

Keywords

Carcinoma Tumorigenesis Netrin signaling pathway Gene set enrichment Molecular association Dependence receptors 

Abbreviations

UNC5B

UNC5 netrin receptor B

PP2A

Protein Phosphate 2A

NTN1

Netrin-1

TS

Thrombospondin domain

DCC

Deleted in colorectal cancer

DAPK

Death-associated protein kinase

IG

Immunoglobulin Domain

DD

Death Domain

PPI

Protein-protein interaction

PTM

Post-translational modification

Notes

Acknowledgments

The work was supported by DST INSPIRE fellowship to Sameer Ahmed Bhat. We also thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka for the support to the Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme (BiSEP) in Multiomics Technology. We also thank the Department of Biotechnology, Government of India, for giving support to Dr. Shaida Andrabi through Ramalingaswami Fellowship.

Compliance with ethical standards

Declaration of interest

The authors report no declarations of interest.

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Copyright information

© The International CCN Society 2018

Authors and Affiliations

  1. 1.Department of BiotechnologyUniversity of KashmirSrinagarIndia
  2. 2.Center for Systems Biology and Molecular MedicineYenepoya (Deemed to be University)MangaloreIndia
  3. 3.Institute of BioinformaticsBangaloreIndia
  4. 4.Manipal Academy of Higher EducationManipalIndia
  5. 5.Department of Surgical Oncology. Yenepoya Medical CollegeYenepoya (Deemed to be University)MangaloreIndia
  6. 6.Department of BiochemistryUniversity of KashmirSrinagarIndia

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