Journal of Cell Communication and Signaling

, Volume 10, Issue 3, pp 207–216 | Cite as

Human pancreatic cancer progression: an anarchy among CCN-siblings

  • Sushanta K. Banerjee
  • Gargi Maity
  • Inamul Haque
  • Arnab Ghosh
  • Sandipto Sarkar
  • Vijayalaxmi Gupta
  • Donald R. Campbell
  • Daniel Von Hoff
  • Snigdha Banerjee
REVIEW

Abstract

Decades of basic and translational studies have identified the mechanisms by which pancreatic cancer cells use molecular pathways to hijack the normal homeostasis of the pancreas, promoting pancreatic cancer initiation, progression, and metastasis, as well as drug resistance. These molecular pathways were explored to develop targeted therapies to prevent or cure this fatal disease. Regrettably, the studies found that majority of the molecular events that dictate carcinogenic growth in the pancreas are non-actionable (potential non-responder groups of targeted therapy). In this review we discuss exciting discoveries on CCN-siblings that reveal how CCN-family members contribute to the different aspects of the development of pancreatic cancer with special emphasis on therapy.

Keywords

CCN1 CCN2 CCN3 CCN4 CCN5 Pancreatic cancer Patient derived xenograft Genetically engineered mice model 

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Copyright information

© The International CCN Society (outside the USA) 2016

Authors and Affiliations

  • Sushanta K. Banerjee
    • 1
    • 2
    • 3
    • 4
  • Gargi Maity
    • 1
    • 3
  • Inamul Haque
    • 1
    • 2
  • Arnab Ghosh
    • 1
    • 2
  • Sandipto Sarkar
    • 1
    • 4
  • Vijayalaxmi Gupta
    • 1
    • 2
  • Donald R. Campbell
    • 5
  • Daniel Von Hoff
    • 6
  • Snigdha Banerjee
    • 1
    • 2
  1. 1.Cancer Research UnitVA Medical CenterKansas CityUSA
  2. 2.Department of OncologyUniversity of Kansas Medical CenterKansasUSA
  3. 3.Department of Pathology and Laboratory MedicineUniversity of Kansas Medical CenterKansasUSA
  4. 4.Department of Anatomy and Cell BiologyUniversity of Kansas Medical CenterKansasUSA
  5. 5.University of Missouri Kansas City and Saint Luke’s HospitalKansas CityUSA
  6. 6.Translational Genomic Research Institute (TGen)PhoenixUSA

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