Journal of Cell Communication and Signaling

, Volume 10, Issue 4, pp 267–272 | Cite as

Epigenetic changes of CDX2 in gastric adenocarcinoma

  • Ali Akbar Samadani
  • Novin Nikbakhsh
  • Maryam Pilehchian
  • Sadegh Fattahi
  • Haleh Akhavan-NiakiEmail author


Gastric cancer is one of the most commonplace and lethal cancers in the world. Molecular investigation of this disease, in order to obtain diagnostic and treatments achievements is important and vital. Relatively, in this research study, one of the most important epigenetic factors, the methylation of CDX2 gene was investigated in tumoral and non-tumoral tissues of gastric cancer patients by bisulfite treatment followed by sequencing of the 5’UTR region of CDX2 in both tissues. The results indicated a hypomethylation in tumoral tissues of adenocarcinoma. Consequently, the methylation amount of CDX2 in tumoral tissues was significantly reduced compared with non-tumoral tissues.


Methylation Gastric cancer UTR CDX2 


Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© The International CCN Society 2016

Authors and Affiliations

  • Ali Akbar Samadani
    • 1
  • Novin Nikbakhsh
    • 2
  • Maryam Pilehchian
    • 3
  • Sadegh Fattahi
    • 1
  • Haleh Akhavan-Niaki
    • 1
    • 3
    Email author
  1. 1.Cellular and Molecular Biology Research CenterBabol University of Medical SciencesBabolIran
  2. 2.Department of SurgeryBabol University of Medical SciencesBabolIran
  3. 3.Department of Genetics, Faculty of MedicineBabol University of Medical SciencesBabolIran

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