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Journal of Cell Communication and Signaling

, Volume 8, Issue 4, pp 289–291 | Cite as

Hormesis: from mainstream to therapy

  • Edward J. Calabrese
Research Article

Abstract

This issue of the Journal of Cell Communication and Cell Signaling on hormetic mechanisms represents an important step in the evolution of the hormesis dose response concept. Since its modern resurgence in the late 1970s the widespread occurrence of hormesis has been in search of its underlying mechanisms. The present integrative set of papers builds upon significant recent advances in the elucidation of hormetic mechanisms and provides the reader with a deep and extensive view of the concept of hormesis from a broad range of researcher perspectives and in many biomedical applications.

Keywords

Biphasic Dose response Hormesis Hormetic J-shaped, U-shaped 

Notes

Acknowledgments

Research activities in the area of dose response have been funded by the United States Air Force and ExxonMobil Foundation over a number of years. However, such funding support has not been used for the present manuscript. The author confirms independence from the sponsors; the content of the article has not been influenced by the sponsors.

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Copyright information

© The International CCN Society 2014

Authors and Affiliations

  1. 1.Department of Public Health, Environmental Health Sciences Morrill I, N344University of MassachusettsAmherstUSA

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