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Journal of Cell Communication and Signaling

, Volume 5, Issue 4, pp 271–275 | Cite as

Salivary proteins as predictors and controls for oral health

  • Dusa Vukosavljevic
  • William Custodio
  • Walter L. SiqueiraEmail author
Commentary

Abstract

We will provide a translational view of using the recent technological advances in dental research for predicting, monitoring, and preventing the development of oral diseases by investigating the diagnostic and therapeutic role of salivary proteins. New analytical state-of-the-art technologies such as mass spectrometry and atomic force microscopy have revolutionized the field of oral biology. These novel technologies open avenues for a comprehensive characterization of the salivary proteins followed by the evaluation of the physiological functions which could make possible in a near future the development of a new series of synthetic protein for therapeutic propose able to prevent global oral diseases such as periodontal disease and dental caries, the two most prevalent oral diseases in the World.

Keywords

Saliva Proteins Proteomics Oral disease Mass spectrometry Atomic Force Microscopy 

Notes

Acknowledgments

Preparation of this article was supported by the CIHR (grant # 106657 and grant # 97577) and NSERC grant #371813. WLS is a recipient of a CIHR New Investigator Salary Award (grant # 113166). The authors have declared no conflict of interest

Conflicts of interest

The authors have declared no conflict of interest.

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Copyright information

© The International CCN Society 2011

Authors and Affiliations

  • Dusa Vukosavljevic
    • 1
  • William Custodio
    • 2
  • Walter L. Siqueira
    • 3
    Email author
  1. 1.Biomedical Engineering Graduate ProgramThe University of Western OntarioLondonCanada
  2. 2.Department of Prosthodontics and PeriodontologyPiracicaba Dental School, State University of CampinasPiracicabaBrazil
  3. 3.Schulich School of Medicine & DentistryThe University of Western OntarioLondonCanada

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