Journal of Cell Communication and Signaling

, Volume 4, Issue 3, pp 119–130 | Cite as

CCN5: biology and pathophysiology

  • Joshua W. Russo
  • John J. CastellotJr.Email author


CCN5 is one of six proteins in the CCN family. This family of proteins has been shown to play important roles in many processes, including proliferation, migration, adhesion, extracellular matrix regulation, angiogenesis, tumorigenesis, fibrosis, and implantation. In this review, we focus on the biological and putative pathophysiological roles of CCN5. This intriguing protein is structurally unique among the CCN family members, and has a unique biological activity profile as well.


CCN proteins Matricellular Nuclear localization Review 


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Copyright information

© The International CCN Society 2010

Authors and Affiliations

  1. 1.Program in Cell, Molecular and Developmental BiologyTufts University Sackler School of Graduate Biomedical SciencesBostonUSA
  2. 2.Department of Anatomy and Cell BiologyTufts University School of MedicineBostonUSA

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