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Chemosensory Perception

, Volume 4, Issue 4, pp 163–174 | Cite as

Use of an Immediate Swallow Protocol to Assess Taste and Aroma Integration in fMRI Studies

  • Sally Eldeghaidy
  • Luca Marciani
  • Johann C. Pfeiffer
  • Joanne Hort
  • Kay Head
  • Andrew J. Taylor
  • Robin C. Spiller
  • Penny A. Gowland
  • Susan FrancisEmail author
Article

Abstract

Perception of flavor is a complex process involving the integration of taste and aroma. Few functional magnetic resonance imaging (fMRI) studies have assessed the crossmodal interactions which result in flavor perception, and all previous studies have used a retro-nasal aroma delivery with a delayed swallow, which delays retro-nasal aroma release, and thus, alters taste and aroma integration. In this paper, we assess crossmodal interactions in flavor processing using an immediate swallow fMRI paradigm in 13 healthy volunteers. We compare unimodal taste (sucrose) and unimodal retro-nasal aroma stimuli, with a congruent taste and aroma combination (flavor), to assess crossmodal flavor interactions using an immediate swallow paradigm. Subtraction and conjunction analysis methods are described, and the use of a control stimulus is addressed. Subtraction analysis was found to reveal areas of anterior insula, frontal operculum, anterior cingulate, and orbitofrontal cortex, whilst the conjunction analysis revealed additional active areas in oral somatosensory areas (SI), rolandic operculum and posterior cingulate, supporting the hypothesis that taste, olfactory, and tactile sensations are integrated to produce a flavor percept.

Keywords

Flavor Taste Aroma Integration Crossmodal fMRI 

Abbreviations used

A

Unimodal aroma stimulus

ACC

Anterior cingulate cortex

APcI-MS

Atmospheric-pressure chemical ionization mass spectrometry

BOLD

Blood oxygenation level dependent

C

Control stimulus

CON

Congruent stimulus

EPI

Echo-planar imaging

fMRI

Functional magnetic resonance imaging

FWE

Family-wise error

FWHM

Full width at half maximum

HRF

Hemodynamic response function

IAA

Isoamyl acetate

INCON

Incongruent stimulus

MNI

Montreal Neurological Institute

OFC

Orbitofrontal cortex

PET

Positron emission tomography

T

Unimodal taste stimulus

TA

Flavor stimulus as in combined taste and aroma stimuli

TE

Echo time

Notes

Acknowledgment

The Biotechnology and Biological Sciences Research Council (Swindon, UK) is thanked for their financial support.

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Copyright information

© Springer Science + Business Media, LLC 2011

Authors and Affiliations

  • Sally Eldeghaidy
    • 1
  • Luca Marciani
    • 2
  • Johann C. Pfeiffer
    • 3
  • Joanne Hort
    • 3
  • Kay Head
    • 1
  • Andrew J. Taylor
    • 3
  • Robin C. Spiller
    • 2
  • Penny A. Gowland
    • 1
  • Susan Francis
    • 1
  1. 1.Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and AstronomyUniversity of NottinghamNottinghamUK
  2. 2.Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Nottingham University HospitalsUniversity of NottinghamNottinghamUK
  3. 3.Flavor Research Group, Division of Food SciencesUniversity of NottinghamLeicestershireUK

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