Hepatology International

, Volume 8, Issue 4, pp 582–587 | Cite as

Clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing Escherichia coli or Klebsiella pneumoniae: a retrospective cohort study

  • Min Jae Kim
  • Kyoung-Ho Song
  • Nak-Hyun Kim
  • Pyoeng Gyun Choe
  • Wan Beom Park
  • Ji Hwan Bang
  • Eu Suk Kim
  • Sang Won Park
  • Hong Bin Kim
  • Hyo-Suk Lee
  • Myoung-don Oh
  • Nam Joong KimEmail author
Original Article



The aim of this study was to (1) evaluate the clinical outcomes of spontaneous bacterial peritonitis (SBP) due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae (EK) and (2) investigate the relationship between the adequacy of initial antibiotic treatments and patient outcomes.


We conducted a retrospective cohort study of cirrhotic patients with SBP caused by EK. We evaluated the 30-day mortality rate and used Cox proportional hazard models to identify risk factors for mortality.


Between January 2006 and December 2012, a total of 231 episodes of SBP due to EK were recorded. Among them, 52 were caused by ESBL-producing EK (ESBL-EK). The 30-day mortality rate was significantly higher in patients with SBP due to ESBL-EK than in those with non-ESBL-producing EK (non-ESBL-EK) (34.6 vs. 18.4 %, respectively; p = 0.013). Multivariate analysis revealed that ESBL production [adjusted HR (aHR) 1.82, 95 % confidence interval (CI) 1.00–3.31], nosocomial infection (aHR 2.24, 95 % CI 1.26–3.95), septic shock (aHR 4.84, 95 % CI 2.70–8.65), higher Child-Pugh score (aHR 1.57, 95 % CI 1.28–1.92), and higher Charlson comorbidity index (aHR 1.37, 95 % CI 1.15–1.64) were independent risk factors for 30-day mortality in the total cohort. When we analyzed patients with SBP due to ESBL-EK separately, septic shock (aHR 3.64, 95 % CI 1.40–9.77), accompanying bacteremia (aHR 3.71, 95 % CI 1.37–10.08), and hepatocellular carcinoma (aHR 3.21, 95 % CI 1.20–8.56) were independent risk factors.


Both 7- and 30-day mortalities for SBP due to ESBL-EK were significantly higher than for SBP due to non-ESBL-EK. Initial antibiotic choice was not associated with poor clinical outcomes in patients with SBP due to ESBL-EK.


Spontaneous bacterial peritonitis ESBL Antibiotics 



There was no financial support for this study.

Compliance with ethical requirements and Conflict of interest

This study was approved by the institutional review board of the Seoul National University Hospital Medical Center (protocol no. 1305-630-491) according to the Helsinki Declaration of 1975, as revised in 2008. Informed consent was waived by the board. Min Jae Kim, Kyoung-Ho Song, Nak-Hyun Kim, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Hyo-Suk Lee, Myoung-don Oh, and Nam Joong Kim declare that they have no conflict of interest.


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Copyright information

© Asian Pacific Association for the Study of the Liver 2014

Authors and Affiliations

  • Min Jae Kim
    • 1
  • Kyoung-Ho Song
    • 1
  • Nak-Hyun Kim
    • 1
  • Pyoeng Gyun Choe
    • 1
  • Wan Beom Park
    • 1
  • Ji Hwan Bang
    • 1
  • Eu Suk Kim
    • 1
  • Sang Won Park
    • 1
  • Hong Bin Kim
    • 1
  • Hyo-Suk Lee
    • 1
  • Myoung-don Oh
    • 1
  • Nam Joong Kim
    • 1
    Email author
  1. 1.Department of Internal Medicine, College of MedicineSeoul National UniversitySeoulRepublic of Korea

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