Hepatology International

, Volume 7, Issue 3, pp 859–868 | Cite as

Roles of alcohol drinking pattern in fatty liver in Japanese women

  • Akio Moriya
  • Yoshiaki Iwasaki
  • Souhei Ohguchi
  • Eizo Kayashima
  • Tadahiko Mitsumune
  • Fusao Ikeda
  • Masaharu Ando
  • Kazuhide Yamamoto
Original Article

Abstract

Purpose

Several studies have reported an inverse association between moderate alcohol consumption and prevalence of fatty liver (FL) in men. We aimed to clarify this association in women.

Methods

We collected health checkup data from 4,921 Japanese women without concurrent liver disease (mean age 46.4 years) and performed a cross-sectional study to evaluate the influence of alcohol drinking patterns (frequency and amount) on the prevalence of FL as assessed by ultrasonography.

Results

Alcohol consumption was reported in 30.8 % of participants, and FL was observed in 13.8 % (15.5 % nondrinkers, 10.1 % drinkers). Alcohol consumption was inversely associated with FL prevalence [adjusted odds ratio (AOR) 0.79, 95 % confidence interval (CI) 0.63–0.98]. In analyses stratified by drinking frequency and/or amount of alcohol consumed, the risk of FL decreased for the following categories: 0.1–19.9 g/drinking day (AOR 0.61, 95 % CI 0.44–0.83) and 0.1–69.9 g/week (AOR 0.74, 95 % CI 0.55–0.98). The amount of alcohol consumed directly correlated with the prevalence of FL in daily drinkers (p < 0.05), whereas there was no correlation between the frequency of alcohol consumption and FL prevalence. Alanine aminotransferase levels were significantly lower for the following categories: 0.1–19.9 g/drinking day for 1–3 days a week (p = 0.016) and 0.1–69.9 g within 1–3 drinking days a week (p = 0.004).

Conclusions

Minimal alcohol consumption appears to have protective effects against nonalcoholic FL disease in women, although an increase in the amount of alcohol consumed appears to nullify the protective effect.

Keywords

Nonalcoholic fatty liver disease Metabolic syndrome Alcohol consumption Drinking frequency Ultrasonography 

Notes

Acknowledgements

No financial support was received.

Conflict of interest

Akio Moriya, Yoshiaki Iwasaki, Souhei Ohguchi, Eizo Kayashima, Tadahiko Mitsumune, Fusao Ikeda, Masaharu Ando, and Kazuhide Yamamoto declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

Compliance with ethical requirements

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

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Copyright information

© Asian Pacific Association for the Study of the Liver 2013

Authors and Affiliations

  • Akio Moriya
    • 1
  • Yoshiaki Iwasaki
    • 2
    • 3
  • Souhei Ohguchi
    • 4
  • Eizo Kayashima
    • 4
  • Tadahiko Mitsumune
    • 4
  • Fusao Ikeda
    • 3
  • Masaharu Ando
    • 1
  • Kazuhide Yamamoto
    • 3
  1. 1.Department of MedicineMitoyo General HospitalKanonjiJapan
  2. 2.Health Service CenterOkayama UniversityOkayamaJapan
  3. 3.Department of Gastroenterology and HepatologyOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical SciencesOkayamaJapan
  4. 4.Junpukai Health Maintenance CenterOkayamaJapan

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