Roles of alcohol drinking pattern in fatty liver in Japanese women
- 142 Downloads
Several studies have reported an inverse association between moderate alcohol consumption and prevalence of fatty liver (FL) in men. We aimed to clarify this association in women.
We collected health checkup data from 4,921 Japanese women without concurrent liver disease (mean age 46.4 years) and performed a cross-sectional study to evaluate the influence of alcohol drinking patterns (frequency and amount) on the prevalence of FL as assessed by ultrasonography.
Alcohol consumption was reported in 30.8 % of participants, and FL was observed in 13.8 % (15.5 % nondrinkers, 10.1 % drinkers). Alcohol consumption was inversely associated with FL prevalence [adjusted odds ratio (AOR) 0.79, 95 % confidence interval (CI) 0.63–0.98]. In analyses stratified by drinking frequency and/or amount of alcohol consumed, the risk of FL decreased for the following categories: 0.1–19.9 g/drinking day (AOR 0.61, 95 % CI 0.44–0.83) and 0.1–69.9 g/week (AOR 0.74, 95 % CI 0.55–0.98). The amount of alcohol consumed directly correlated with the prevalence of FL in daily drinkers (p < 0.05), whereas there was no correlation between the frequency of alcohol consumption and FL prevalence. Alanine aminotransferase levels were significantly lower for the following categories: 0.1–19.9 g/drinking day for 1–3 days a week (p = 0.016) and 0.1–69.9 g within 1–3 drinking days a week (p = 0.004).
Minimal alcohol consumption appears to have protective effects against nonalcoholic FL disease in women, although an increase in the amount of alcohol consumed appears to nullify the protective effect.
KeywordsNonalcoholic fatty liver disease Metabolic syndrome Alcohol consumption Drinking frequency Ultrasonography
No financial support was received.
Conflict of interest
Akio Moriya, Yoshiaki Iwasaki, Souhei Ohguchi, Eizo Kayashima, Tadahiko Mitsumune, Fusao Ikeda, Masaharu Ando, and Kazuhide Yamamoto declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.
Compliance with ethical requirements
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.
- 8.Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, et al. Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group. Gut 1997;41:845–850Google Scholar
- 21.Examination Committee of Criteria for ‘Obesity Disease’ in Japan, Japan Society for the Study of Obesity. New criteria for ‘obesity disease’ in Japan. Circ J 2002;66:987–992Google Scholar
- 23.R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2012. http://www.R-project.org/. Retrieved 27 Oct 2012
- 24.Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002;137:1–10Google Scholar