Hepatology International

, Volume 7, Issue 2, pp 413–428

Should visceral fat, strictly linked to hepatic steatosis, be depleted to improve survival?

Review Article


Numerous epidemiologic studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 diabetes mellitus, cardiovascular disease, stroke, metabolic syndrome and its further expression, i.e., nonalcoholic fatty liver disease and death. Using novel models of visceral obesity, several studies have demonstrated that the relationship between visceral fat and longevity is causal, while the accrual of subcutaneous fat does not appear to play an important role in the etiology of disease risk. The need of reducing the visceral fat to improve survival, mainly taking into account the strict link between nonalcoholic fatty liver disease and the coronary artery disease is discussed.



Copyright information

© Asian Pacific Association for the Study of the Liver 2012

Authors and Affiliations

  1. 1.Center of Obesity and Eating DisorderStella Maris Mediterraneo Foundation ChiaromontePotenzaItaly
  2. 2.Department of Clinical and Experimental MedicineFederico II University Medical School of NaplesNaplesItaly

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