Hepatology International

, Volume 6, Issue 3, pp 598–605

Host genetic variants and hepatitis B virologic features in HBeAg-negative hepatitis B carriers with long-term biochemical remission

  • Chih-Lin Lin
  • Tai-Chung Tseng
  • Tung-Hung Su
  • Chun-Jen Liu
  • Pei-Jer Chen
  • Ming-Yang Lai
  • Ding-Shinn Chen
  • Jia-Horng Kao
Original Article

Abstract

Purpose

A significant portion of HBeAg-negative chronic hepatitis B patients have persistently normal serum alanine aminotransferase levels (PNALT). We thus investigated host genetic variants and virological features in HBeAg-negative hepatitis B carriers.

Methods

Baseline clinical and virological features of 133 HBeAg-negative hepatitis B carriers (77 with PNALT and 56 with chronic hepatitis activity) with follow-up for more than 5 years were investigated. Three single nucleotide polymorphisms (SNPs) located within or around human leukocyte antigen (HLA)-DPA1, HLA-DPB1, and interleukin (IL) 28B loci were genotyped.

Results

The genotype frequencies of these SNPs were comparable between hepatitis B carriers with PNALT and those with chronic hepatitis. Compared with hepatitis B carriers with PNALT, those with chronic hepatitis had significantly higher baseline serum HBV-DNA levels (4.96 vs. 4.04 log10 IU/ml, P = 0.001). Baseline serum HBV-DNA level > 2000 IU/ml (OR, 8.42; 95% CI, 2.74–25.90, P < 0.001) were the only independent factor associated with chronic hepatitis activity. Changes of serum HBV-DNA in 30 hepatitis B carriers with PNALT had showed a significant reduction of viral load from baseline to last visit (mean difference of paired HBV-DNA levels: −0.78 log10 IU/ml, 95% CI: −1.57 to −0.013, P = 0.047). In contrast, no significant reduction of viral load was found in 28 patients with chronic hepatitis.

Conclusions

The results indicate that lower baseline serum HBV-DNA level and viral load reduction over time are associated with long-term biochemical remission in HBeAg-negative hepatitis B carriers.

Keywords

HBeAg-negative carrier Hepatitis B virus HBV-DNA Alanine aminotransferase Host genetic variants 

Copyright information

© Asian Pacific Association for the Study of the Liver 2011

Authors and Affiliations

  • Chih-Lin Lin
    • 1
    • 2
  • Tai-Chung Tseng
    • 3
  • Tung-Hung Su
    • 4
  • Chun-Jen Liu
    • 4
    • 5
    • 6
  • Pei-Jer Chen
    • 4
    • 5
  • Ming-Yang Lai
    • 4
    • 5
  • Ding-Shinn Chen
    • 4
  • Jia-Horng Kao
    • 4
    • 5
    • 6
    • 7
  1. 1.Department of GastroenterologyTaipei City Hospital, Ren-Ai branchTaipeiTaiwan
  2. 2.Department of PsychologyNational Chengchi UniversityTaipeiTaiwan
  3. 3.Division of Hepatogastroenterology, Department of Internal MedicineBuddhist Tzu Chi General Hospital, Taipei BranchTaipeiTaiwan
  4. 4.Department of Internal MedicineNational Taiwan University HospitalTaipeiTaiwan
  5. 5.Graduate Institute of Clinical MedicineNational Taiwan University College of MedicineTaipeiTaiwan
  6. 6.Hepatitis Research CenterNational Taiwan University College of Medicine, National Taiwan University HospitalTaipeiTaiwan
  7. 7.Department of Medical ResearchNational Taiwan University College of Medicine, National Taiwan University HospitalTaipeiTaiwan

Personalised recommendations