Hepatology International

, Volume 4, Issue 3, pp 548–561 | Cite as

New antiviral therapies for chronic hepatitis C

Review Article


Chronic hepatitis C is an important health issue worldwide. The current standard therapy is based on a combination of pegylated-interferon (pegIFN) and ribavirin (RBV), but this treatment leads to only ~50% sustained virological response (SVR) in patients with HCV genotype 1 and high viral loads, who were mostly null-responders or relapsers. Among HCV genotypes other than HCV genotype 1, especially HCV genotype 4 patients show only 40–70% SVR by this treatment. Although new drugs also depend on the combination of pegIFN and RBV, it appears that these drugs improve not only rapid virological response (RVR) but also early virological response, leading to SVR in these patients. In the near future, we predict higher SVR rates in chronic hepatitis C patients treated with these new drugs.


EVR Protease inhibitor Polymerase inhibitor Ribavirin Vitamin D 



The authors thank Prof. Ranjit Ray and Ratna Ray, Saint Louis University, USA, for valuable discussions. This work was supported by the Japan Science and Technology Agency, Ministry of Education, Culture, Sports, Science and Technology, Japan [21590829 (T.K.), 21590828 (F.I.), and 21390225 (O.Y.)] and by research grants from the Foundation for Advancement of International Science, Japan (T.K.) and the Viral Hepatitis Research Foundation of Japan (T.K.).


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Copyright information

© Asian Pacific Association for the Study of the Liver 2010

Authors and Affiliations

  1. 1.Department of Medicine and Clinical Oncology, Graduate School of MedicineChiba UniversityChibaJapan

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