Hepatology International

, Volume 2, Issue 4, pp 498–499 | Cite as

Reactivation of chronic hepatitis B infection related to imatinib mesylate therapy

  • Shilen Lakhani
  • Lev Davidson
  • Dennis A. Priebat
  • Averell H. SherkerEmail author
Case Report


Imatinib (Gleevec, Novartis), an inhibitor of BCR-ABL, platelet-derived growth factor, and KIT receptor tyrosine kinases, is widely used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. We describe a case of activation of chronic hepatitis B infection associated with imatinib therapy.


Chronic hepatitis B infection Imatinib mesylate 


  1. 1.
    Lok AS, McMahon BJ. Chronic hepatitis B: update of recommendations. Hepatology 2004;39(3):857–861PubMedCrossRefGoogle Scholar
  2. 2.
    Rubin BP, Heinrich MC, Corless CL. Gastrointestinal stromal tumour. Lancet 2007;369(9574):1731–1741PubMedCrossRefGoogle Scholar
  3. 3.
    Mace J, Sybil Biermann J, Sondak V, et al. Response of extraabdominal desmoid tumors to therapy with imatinib mesylate. Cancer 2002;95(11):2373–2379PubMedCrossRefGoogle Scholar
  4. 4.
    Appel S, Boehmler AM, Grunebach F, et al. Imatinib mesylate affects the development and function of dendritic cells generated from CD34+ peripheral blood progenitor cells. Blood 2004;103(2):538–544PubMedCrossRefGoogle Scholar
  5. 5.
    James C, Trouette H, Marit G, Cony-Makhoul P, Mahon FX. Histological features of acute hepatitis after imatinib mesylate treatment. Leukemia 2003;17(5):978–979PubMedCrossRefGoogle Scholar
  6. 6.
    Ikeda K, Shiga Y, Takahashi A, et al. Fatal hepatitis B virus reactivation in a chronic myeloid leukemia patient during imatinib mesylate treatment. Leuk Lymphoma 2006;47(1):155–157PubMedCrossRefGoogle Scholar

Copyright information

© Asian Pacific Association for the Study of the Liver 2008

Authors and Affiliations

  • Shilen Lakhani
    • 1
  • Lev Davidson
    • 2
  • Dennis A. Priebat
    • 2
  • Averell H. Sherker
    • 1
    Email author
  1. 1.Section of Gastroenterology and Hepatology, Washington Hospital CenterGeorgetown University School of MedicineWashingtonUSA
  2. 2.Washington Cancer Institute, Washington Hospital CenterGeorgetown University School of MedicineWashingtonUSA

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