A Rare Case of Ossifying Fibroma with Cystic Degeneration: Diagnostic Challenge with Literature Review

  • Gitika Sharma
  • Mala KambojEmail author
  • Anjali Narwal
  • Anju Devi
  • Virendra Singh
  • Ambika Gupta
Clinical Report


Cystic degeneration can occur with various bone lesions. These non-epithelial lined cysts vary from aneurysmal bone cyst, solitary bone cyst or non specific cystic degeneration. In jaws, this association is not well documented. In literature only three cases have been reported as ossifying fibroma (OF) with cystic degeneration. This case appears to be the fourth case to highlight non specific cystic changes in OF. We report a case of OF in 23 year old female with asymptomatic swelling over the left side of face for the past 3 years involving the maxilla, maxillary sinus as well as nasal cavity. Histopathology revealed it to be OF complicated by non-specific cystic degeneration. OF of jaws is an odontogenic neoplasm arising from tooth bearing areas. It occurs more commonly in women in posterior mandible region. Microscopically it shows variable mixture of osteoid bone and basophilic acellular spherules while bony trabeculae frequently demonstrate both woven and lamellar patterns. Various pathogenesis have also been highlighted behind the cystic degeneration’s in bony lesions. A review is also tabulated of OFs with cystic degenerations in the jaws reported in the past.


Ossifying fibroma Cystic degeneration Non-specific Epithelialization 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Waldron CA (1985) Fibro-osseous lesions of the jaws. J Oral Maxillofac Surg 43:249–262CrossRefGoogle Scholar
  2. 2.
    Bahl R, Sandhu S (2012) Benign fibro-osseous lesions of the jaws. IDJSR 1(2):56–68Google Scholar
  3. 3.
    Khan SA, Kumar N (2011) Ossifying fibroma of maxilla in male child. Natl J Maxillofac Surg 2(1):73–79CrossRefGoogle Scholar
  4. 4.
    Alawi F (2002) Benign fibro-osseous diseases of the maxillofacial bones. A review and differential diagnosis. Am J Clin Pathol 118 Suppl:S50–S70Google Scholar
  5. 5.
    Ferreti C, Coleman H (1999) Cystic degeneration in fibrous dysplasia of jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 88(3):337–342CrossRefGoogle Scholar
  6. 6.
    Bahk WJ, Kang YK, Rhee SK, Chung YG, Lee AH, Bahk YW (2007) Cystic fibrous dysplasia in the long bone. Orthopedics 30(10):871–873Google Scholar
  7. 7.
    Oliver LP (1973) Aneurysmal bone cyst: report of a case. Oral Surg Oral Med Oral Pathol 35(1):67–76CrossRefGoogle Scholar
  8. 8.
    Gnanadeepam S, Ponniah I (2012) Ossifying fibroma with non specific cystic degeneration. Oral Maxillofac Surg 16:101–105. CrossRefGoogle Scholar
  9. 9.
    Nasim A, Wadhwan V (2016) Aneurysmal bone cyst secondary to ossifying fibroma. IOSR JDMS 15(12):71–77. Google Scholar
  10. 10.
    Boyd RC (1979) Aneurysmal bone cyst of jaws. Br J Oral Surg 16:248–253CrossRefGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2019

Authors and Affiliations

  1. 1.Department of Oral and Maxillofacial Pathology and Oral Microbiology, Post Graduate Institute of Dental SciencesPt. BD Sharma University of Health SciencesRohtakIndia
  2. 2.Department of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental SciencesPt. BD Sharma University of Health SciencesRohtakIndia
  3. 3.Department of Oral Medicine and Radiology, Post Graduate Institute of Dental SciencesPt. BD Sharma University of Health SciencesRohtakIndia

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