Randomised Controlled Clinical Study of Injection Caroverine and Ginkgo Biloba Extract in Cochlear Synaptic Tinnitus
Tinnitus, also known as phantom auditory perception, is an annoying symptom and 13–17% of population reports bothersome tinnitus. Cochlear synaptic tinnitus is the most common type. Many treatments have been tried but none is yet considered to be well established. To evaluate effect of Inj.Caroverine and Ginkgo Biloba extract in cochlear synaptic tinnitus in terms of improving tinnitus grading, tinnitus matching and quality of life of patient. It is Randomised controlled study, conducted in department of ENT, on 86 patients, who met inclusion criteria, divided into 4 groups. Gr1—Inj Caroverin, Gr2—Inj Placebo, Gr3—Ginkgo Biloba extract, Gr4—Placebo as extract. A single dose infusion of caroverine immediately improves tinnitus grading and matching and provides immediate relief in reducing severity of tinnitus in 54.54% cases but improvement was not sustained in caroverine group at 3 month and 6 month follow-up after infusion. Ginkgo biloba also is effective in improving tinnitus grading and matching in 31.8% cases and improvement was sustained in ginkgo biloba group even after 3 month of cessation of treatment i.e. at 6 month follow-up. It is suggested that Inj.Caroverine as intravenous infusion should be given in severe cases of tinnitus to reduce its severity immediately and then patient should be put on Tab.Ginkgo biloba for a period of 3 months to provide sustained and long lasting relief. Thus combination therapy of Inj.Caroverin and Tab.Ginkgo Biloba, appropriately tailored to the need of patient will provide better results in greater majority of patients.
KeywordsTinnitus Injection caroverine Ginkgo biloba extract Cochlear Cochlear synaptic tinnitus
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 3.Cooper JC Jr (1994) Tinnitus, subjective hearing loss and well being. Health and Nutrition Examination Survey of 1971–75: part II. J Am Acad Audiol 5:37–43Google Scholar
- 5.Tyler RS, Kesely D (1990) Advantages and disadvantages reported by some of the better cochlear- implant patients. Am J Otol 11:282–289Google Scholar
- 6.Shulman A, Goldstein B (1996) A final common pathway for tinnitus. Implications for treatment. Int Tinnitus J 2:137–142Google Scholar
- 8.Murai K, Tyler RS, Harker LA, Sttoufer JL (1992) Review of pharmacological treatment of tinnitus. Am J Otol 13:454–464Google Scholar
- 16.Meyer B (1986) Etude multicentrique randomise a double insuface au placebo du traitment des acouphenes par I’ extrait Ginkgo biloba. La Presse Med 15(1562):1564Google Scholar