Isolated Laryngeal Leishmaniasis: A Diagnostic Dilemma

  • Karan Aggarwal
  • Rajeev KumarEmail author
  • Nishu Bhardwaj
  • Bhinyaram Jat
  • Rakesh Kumar
Clinical Report


Isolated laryngeal Leishmaniasis is a rare entity in the Indian subcontinent. We describe a case of a 45 year old male with hoarseness and noisy breathing. Patient’s initial histological and serological workup was inconclusive. Final biopsy findings (suggestive of Leishmania donovani), positive rK-39 serology and his native place being Bihar (endemic for Leishmaniasis) led us to the diagnosis. He was treated with high dose liposomal Amphotericin B to which he responded well. This case report highlights the importance of remaining aware of rare infectious causes of laryngitis. Timely diagnosis and intervention are crucial.


Leishmaniasis Laryngeal Mucosal Laryngitis 



We would like to acknowledge the efforts of our pathologists at the institute to have helped us in reaching closer to the diagnosis.

Compliance with Ethical Standards

Conflict of interest

The authors do not hold any conflicts of interest.

Ethical Standard

This clinical case report does not describe any interventional research involving human participants or animals, however describes a unique diagnostic dilemma.

Informed Consent

Institutional informed-written consent was taken from the patient at all appropriate times.


  1. 1.
    Status of endemicity of visceral leishmaniasis worldwide (2015) Countries reporting imported VL cases, 2015Google Scholar
  2. 2.
    Status of endemicity of cutaneous leishmaniasis worldwide (2015), 2017Google Scholar
  3. 3.
    General C, Who I (2014) Leishmaniasis, 2013–2014Google Scholar
  4. 4.
    Marsden PD (1986) Mucosal leishmaniasis. Trans R Soc Trop Med Hyg 80:859–876CrossRefGoogle Scholar
  5. 5.
    Tayal S, Khatiwada S, Sehrawat P, Nischal N, Jorwal P, Soneja M et al (2015) Laryngeal leishmaniasis with extra-pulmonary tuberculosis. J Assoc Physicians India 2015(63):71–73Google Scholar
  6. 6.
    Kumar B, Ghimire A, Karki S, Upadhyaya P (2009) Primary laryngeal leishmaniasis: a rare case report. Indian J Pathol Microbiol 52(1):62–64CrossRefGoogle Scholar
  7. 7.
    Leoncini E, Ricciardi W, Cadoni G, Arzani D, Petrelli L, Paludetti G et al (2014) Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium. Head Neck 36(10):1391Google Scholar
  8. 8.
    Zijlstra EE, Daifalla NS, Kager PA, Khalil EAG, El-Hassan AM, Reed SG et al (1998) rK39 Enzyme-linked immunosorbent assay for diagnosis of Leishmania donovani infection. Clin Diagn Lab Immunol 5(5):717–720PubMedPubMedCentralGoogle Scholar
  9. 9.
    Vaish M, Singh OP, Chakravarty J, Sundar S (2012) rK39 antigen for the diagnosis of visceral leishmaniasis by using human saliva. Am J Trop Med Hyg 86(4):598–600CrossRefGoogle Scholar
  10. 10.
    NASCOP (2014) Guidelines on use of rk39-NVBDCP.
  11. 11.
    Sundar S, Chakarvarty J, Agarwal D, Rai M, Murray HW (2010) Single-dose liposomal Amphotericin-B for visceral leishmaniasis in India. N Engl J Med 362(6):504–512CrossRefGoogle Scholar
  12. 12.
    Toledo SJ, Valda L, Balderrama M, Rea I, Parra R, Ardiles J et al (2007) Treatment of bolivian mucosal leishmaniasis with miltefosine. Clin Infect Dis 44(3):350–356CrossRefGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2019

Authors and Affiliations

  1. 1.4057, Department of Otorhinolaryngology and Head & Neck SurgeryAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of PathologyAll India Institute of Medical SciencesNew DelhiIndia

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