Long-Term Therapy with Corticosteroids in Nasal Polyposis: A Bone Metabolism Assessment

  • M. Gelardi
  • F. Barbara
  • I. Covelli
  • M. A. Damiani
  • F. Plantone
  • A. Notarnicola
  • B. Moretti
  • N. Quaranta
  • G. CiprandiEmail author
Original Article


Chronic rhinosinusitis associated with nasal polyposis (RSCwNP) affects 4% of the general population. As chronic condition, it requires chronic pharmacological treatment, whereas the surgical approach becomes necessary in obstructive and/or complicated cases. Intranasal and systemic corticosteroids (CS) represent the “Gold Standard” treatment for RSCwNP. The present study aimed to evaluate the side effects of prednisone in a group of patients with RSCwNP treated with long-term CS. In particular, attention was focused on bone disorders (osteopenia and osteoporosis) and prospective fracture risk increase. Forty patients (26 females, mean age 55.70 ± 14.03 years) affected by RSCwNP have been enrolled. Control group included 40 healthy subjects (17 females, mean age 56.37 ± 13.03 years). Nasal endoscopy, skin prick tests, nasal cytology, and bone densitometry were evaluated in all subjects. The likelihood of impaired bone metabolism (osteopenia or osteoporosis) was superimposable in both groups. Within RSCwNP group, no parameter was statistically significant in predicting a metabolism alteration.


Chronic rhinosinusitis Nose-sinus polyposis Corticosteroids Densitometry Osteoporosis 


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Copyright information

© Association of Otolaryngologists of India 2018

Authors and Affiliations

  1. 1.Otolaryngology Unit, Department of Basic Medical Science, Neuroscience and Sensory OrgansUniversity of Bari Aldo MoroBariItaly
  2. 2.Orthopaedic, Trauma and Spine Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of MedicineUniversity of Bari Aldo Moro, AOU Consorziale PoliclinicoBariItaly
  3. 3.Ospedale Policlinico San MartinoGenoaItaly

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