Hyalinizing Clear Cell Carcinoma: Base of Tongue

  • Nataraj PillaiEmail author
  • Partheeban Balasundaram
  • Nehla Isaac
Clinical Report


Hyalinizing clear cell carcinoma (HCCC) is a low grade, rare neoplasm originating from the minor salivary glands. It usually follows an indolent course and the main treatment modality is surgery. The prognosis of these tumours are good, hence it needs to be differentiated from other carcinomas with clear cells. Here we report a pathologically proven HCCC of the base of tongue.


Hyalinizing clear cell carcinoma Base of tongue Minor salivary gland tumour 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed Consent

Formal consent is not required for this type of study (clinical report). Informed consent was obtained from the patient for the surgical procedure.

Ethical Standards

All procedures performed in the study were in accordance with the ethical standards of the institution and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


  1. 1.
    Milchgrub S, Gnepp DR, Vuitch F, Delgado R, Albores-Saavedra J (1994) Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol 18:74–82CrossRefGoogle Scholar
  2. 2.
    Balakrishnan R, Nayak DR, Pillai S et al (2002) Hyalinizing clear cell carcinoma of the base of the tongue. J Laryngol Otol 116:851–853CrossRefGoogle Scholar
  3. 3.
    Daniele L, Nikolarakos D, Keenan J et al (2016) Clear cell carcinoma, not otherwise specified/hyalinising clear carcinoma of the salivary gland: the current nomenclature, clinical/pathological characteristics and management. Crit Rev Oncol Hematol 102:55–64CrossRefGoogle Scholar
  4. 4.
    O’Sullivan-Mejia ED, Massey HD, Faquin WC, Powers CN (2009) Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. Head Neck Pathol 3(3):179–185CrossRefGoogle Scholar
  5. 5.
    Masilamani S, Rao S, Chirakkal P, Kumar AR (2011) Hyalinising clear cell carcinoma of the base of tongue: a distinct and rare entity. Indian J Pathol Microbiol 54(1):167–169CrossRefGoogle Scholar
  6. 6.
    Farooq S, Harding-Jackson N, Stadler M, Freitag F (2016) Hyalinizing clear cell carcinoma of the base of tongue: first report of a case presenting with headaches. Neurology 86(16):P6.094Google Scholar
  7. 7.
    Suzuki H, Katoh A, Udaka T, Shiomori T, Fujimura T, Fujimura K, Kitamura T (2006) Hyalinizing clear cell carcinoma arising from the base of the tongue. Acta Otolaryngol 126(6):653–656CrossRefGoogle Scholar
  8. 8.
    Pujary K, Rangarajan S, Nayak DR, Balakrishnan R, Ramakrishnan V (2008) Hyalinizing clear cell carcinoma of the base of tongue. Int J Oral Maxillofac Surg 37(1):93–96 Epub 2007 Sep 5 CrossRefGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2019

Authors and Affiliations

  1. 1.Department of ENTSRM Institutes for Medical Science (SIMS) HospitalsChennaiIndia
  2. 2.Department of PathologySRM Institutes for Medical Science (SIMS) HospitalsChennaiIndia

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