The Correlation of Allergic Rhinitis with ABO Phenotype
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The aim of study the correlation of ABO phenotypes in patients of allergic rhinitis and controls and to compare our study with the previous studies to analyse the association of above. 100 patients with symptoms of allergic rhinitis and 100 controls individual were selected from same geographical region and paired by gender and age were enrolled in the study. Detailed history, examination and relevant radiological and hematological investigations were done. ABO phenotypes were identified in red blood cells using hemagglutination technique. This clinic-based observational study was conducted among the patients presenting with signs and symptoms of allergic rhinitis. Maximum no. of cases were seen in ABO phenotype O (52%), followed by A, B and AB (33, 12 and 3% respectively) and it was found to be statistically significant (p = 0.001). Also more number of male patients were found in B and O blood group which was statistically significant (OR 5.33, p = 0.017 and OR 3.63, p = 0.006 respectively). Controls showed marginalized difference in distribution among the basis of different ABO phenotypes. The O blood group phenotype of ABO histo-blood group system is associated with AR. This study contributes to the better understanding of the pathophysiology and clinical variability of this disease and may help to improve strategies towards its prevention and diagnosis. Additionally, ABO histo-blood group phenotyping, an inexpensive and easy to perform assay could be used to identify individuals at risk of developing allergic rhinitis.
KeywordsAllergic rhinitis ABO phenotype O blood group
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no competing interests.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 3.Karabulut K, Baysal S, Acar B, Babademez MA, Karasen MR (2011) Allergic rhinitis in geriatric patients. Arch Gerontol Geriatr 5:2414–2444Google Scholar
- 12.Saini M, Yadav AS (2014) Distribution of ABO & Rh (D) allele frequency among asthmatic patients. IMPACT Int J Res Appl Nat Soc Sci (IMPACT: IJRANSS) 2(5):217–222Google Scholar
- 14.Al-Shamma YMH, Al-Zubaidy AM, Al-Turjoman AA (2008) The Association of Bronchial Asthma to (ABO) Blood Groups in Najaf Governorate. Kufa Med J 11(1):234–245Google Scholar
- 22.Canonica GW, Mullol J, Pradalier A, Didier A (2008) Patient perceptions of allergic rhinitis and quality of life findings from a survey conducted in Europe and the United States. WAO J 1:138–144Google Scholar
- 27.Filsoufi J (1975) Statistical study of the relationship between allergic diseases and the blood group. Fr J Allerg Clin Immunol 15(2):115–117Google Scholar
- 29.de la Vega AR, Cortes JG, Gallestey JB (1976) Genetics polymorphisms of ABO and Rh system in relation to bronchial asthma: preliminary report. Allergol Immunopathol (Madr) 4:305–310Google Scholar
- 30.Anand S (1964) The relationship of ABO, MN, and Rhesus blood groups to asthma. Indian J Chest Dis Allied Sci 6:74Google Scholar