Evaluation of Serum Selenium and Erythrocyte Glutathione Peroxidase Levels in Patients with Recurrent Tonsillitis

  • Metin Kilinc
  • Cem Kastal
  • Erdogan OkurEmail author
  • Ilhami Yildirim
Original Article


The aim of this study is to investigate serum selenium (Se) and glutathione peroxidase (GSH-Px) levels in patients with recurrent tonsillitis. The study included 53 patients with recurrent tonsillitis and 51 healthy children. The measurement of serum Se levels were done in graphite furnace atomic absorption spectrophotometer using Zeeman background correction. Erythrocyte GSH-Px levels were indirectly measured by using the spectrophotometry. The ages of children in both groups ranged between 3 and 13 years, with a mean age of 7.60 years for patient group and 7.22 years for control group. Mean serum Se levels in patient and control groups were 60.4 and 78.7 µg/dL respectively. Mean erythrocyte GSH-Px levels in patient and control groups were 7.0 and 23.1 U/g hb, respectively. The mean blood Se and GSH-Px levels in patients with recurrent tonsillitis were significantly (P < 0.001) lower than control group. In our study, we found that serum Se and erythrocyte GSH-Px levels of cases with recurrent tonsillitis were significantly lower than healthy controls. The decline in serum Se and erythrocyte GSH-Px enzyme levels may predispose a chronic disease state but this issue needs further investigation.


Selenium Glutathione peroxidase Recurrent tonsillitis Trace element Oxidant Antioxidant 



We thank Prof. Dr. Prem Gathiram (Ph.D.) for grammatical corrections.

Compliance with Ethical Standards

Conflict of interest

All authors declare that they have no conflict of interest.


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Copyright information

© Association of Otolaryngologists of India 2017

Authors and Affiliations

  • Metin Kilinc
    • 1
  • Cem Kastal
    • 2
  • Erdogan Okur
    • 3
    Email author
  • Ilhami Yildirim
    • 4
  1. 1.Department of Biochemistry, School of MedicineKahramanmaras Sutcu Imam UniversityKahramanmarasTurkey
  2. 2.Department of OtorhinolaryngologySilifke State HospitalSilifkeTurkey
  3. 3.Department of Otorhinolaryngology, School of MedicineSuleyman Demirel University, SDU Dogu Yerleskesi, Arastirma ve Uygulama Hastanesi KBB poliklinigiIspartaTurkey
  4. 4.Department of OtorhinolaryngologyAdana Numune State HospitalYuregirTurkey

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