Primary Spheno-Petro-Clival Tuberculosis

  • Hitesh VermaEmail author
  • Smriti Panda
  • Kapil Sikka
  • David Victor Kumar Irugu
  • Alok Thakar
Original Article


The increase awareness and advent of anti-tuberculosis therapy led to decline in tuberculosis. Now a resurgence of tuberculosis is with immunosuppression and with resistant strains. The detection rate of extrapulmonary is increased with the advent of newer modalities of detection, imaging, and better testing. This case series documents our experience with seven cases of primary spheno-petro-clival lesion and details of the clinical and radiological presentations of these patients. Intraoperative obtained tissue was send for histopathological and microbiological evaluation. The most common symptoms were headache and nasal discharge. The final diagnosis of spheno-petro-clival tuberculosis was confirmed in all cases with histopathology and by culture post-operatively. Skull base tuberculosis is relative rare entity in past because of late occurrence of specific symptom, incomplete radiological evaluation and it may present as neck swelling by travelling through various neck spaces. (1) Tubercular infection should be considered as differential in skull base lesion as pickup rate is increasing with advancement in technology. (2) Two of our cases had retropharyngeal abscess have focus in skull base bone. The skull base, hence, may be one of foci in undetermined sites of tuberculous infections and should be searched for.


Tuberculosis Spheno-petro-clival region Skull base Infection Paranasal sinuses 



We are thankful to Director and Head of Department for allowing us to use data.

Author Contribution

Dr Hitesh Verma was involved in designing, collection of data and drafting of article. Dr Smriti Panda, Dr Kapil Sikka and Dr David Victor Kumar Irugu were contributes in analysing and interpretation of data. Dr Alok Thakar was substantial contributions in conception, design, and final approval of article.

Compliance with Ethical Standards

Ethical Approval

This article does not contain any studies with human participants performed by any of the authors.

Informed Consent

The study is based on radiological finding and patient case file.


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Copyright information

© Association of Otolaryngologists of India 2017

Authors and Affiliations

  • Hitesh Verma
    • 1
    Email author
  • Smriti Panda
    • 1
  • Kapil Sikka
    • 1
  • David Victor Kumar Irugu
    • 1
  • Alok Thakar
    • 1
  1. 1.Department of Otorhinolaryngology, Head & Neck SurgeryAll India Institute of Medical SciencesNew DelhiIndia

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