Acute Thyroid Profile Changes During External Beam Irradiation of Neck

  • Nishant Madhani
  • Surendra Kumar SainiEmail author
  • Shelly Srivastava
  • S. K. Agarwal
  • P. Odedara
Original Article


Thyroid gland is irradiated to a considerable dose in conventional radiotherapy of head neck cancer and significant proportion of patients later develop hypothyroidism. This study is an effort to shed light on acute changes in thyroid function after irradiation those are less clearly defined. Values were recorded before radiation treatment, after 4 week of irradiation, after completion of treatment, 1 month after completion of treatment and after 4 months of completion of treatment. A repeated measures ANOVA with a Greenhouse–Geisser correction determined that mean T3, T4 and TSH levels differed statistically significantly between time points. Post hoc test using the Bonferroni correction revealed statistical significance difference in values of T3, T4 and TSH done at specific intervals. External irradiation in cancer therapeutic doses affects thyroid function and sets at a new point with increased TSH, but in reference ranges, to maintain required thyroxin level.


Thyroid hormone Thyroid profile Head neck cancer Radiotherapy Acute changes 


Compliance with Ethical Standards

Conflict of interest

None of the author has conflict of interest to disclose.

Human and Animal Right Statements

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Association of Otolaryngologists of India 2017

Authors and Affiliations

  • Nishant Madhani
    • 1
  • Surendra Kumar Saini
    • 1
    Email author
  • Shelly Srivastava
    • 1
  • S. K. Agarwal
    • 1
  • P. Odedara
    • 2
  1. 1.Department of RadiotherapyG G Govt Hospital and M P Shah Govt Medical CollegeJamnagarIndia
  2. 2.Department of Medical PhysicsG G Govt Hospital and M P Shah Govt Medical CollegeJamnagarIndia

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