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Myeloid Sarcoma of Temporal Bone: A Rare Manifestation of Relapse Acute Myeloid Leukemia

  • Bee See GohEmail author
  • Chian Ling Tang
  • Geok Chin Tan
Clinical Report
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Abstract

Myeloid sarcoma is a rare malignant extramedullary neoplasm of myeloid precursor cells. This disorder may occur in concomitance with or precede development of acute or chronic myeloid leukemia. Sometimes, it is the initial manifestation of relapse in a previously treated acute myeloid leukemia. We report a case of 11 years old boy with acute myeloid leukemia in remission state, presented with short history of right otalgia associated with facial nerve palsy. Diagnosis of right acute mastoiditis with facial nerve palsy as complication of acute otitis media was made initially. Patient underwent simple cortical mastoidectomy but histopathology from soft tissue that was sent revealed diagnosis of myeloid sarcoma. A leukemic relapse was confirmed by paediatric oncologist through bone marrow biopsy. Chemotherapy was commenced but patient responded poorly to the treatment.

Keywords

Myeloid sarcoma Acute mastoiditis Acute myeloid leukemia Facial nerve palsy 

Notes

Compliance with Ethical Standards

Conflict of interest

Authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any authors.

Informed consent

Informed consent was obtained from all individual participants included in this study.

References

  1. 1.
    Jaffe ES, Harris NL, Stein H, Vardiman JW (2001) Pathology and genetics. Tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 104–105Google Scholar
  2. 2.
    Pileri SA et al (2007) Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 21(2):340–350CrossRefGoogle Scholar
  3. 3.
    Dusenbery KE, Howells WB, Arthur DC, Alonzo T, Lee JW, Kobrinsky N, Barnard DR, Wells RJ, Buckley JD, Lange BJ, Woods WG (2003) Extramedullary leukemia in children with newly diagnosed acute myeloid leukemia: a report from the Children’s Cancer Group. J Pediatr Hematol Oncol 25(10):760–768CrossRefGoogle Scholar
  4. 4.
    Joseph DE, Durosinmi MA (2008) Neurological complications of chronic myeloid leukaemia: any cure? Niger J Clin Pract 11(3):246–249PubMedGoogle Scholar
  5. 5.
    Todd NW Jr, Bowman CA (1984) Acute myelogenous leukemia presenting as atypical mastoiditis with facial paralysis. Int J Pediatr Otorhinolaryngol 7(2):173–177CrossRefGoogle Scholar
  6. 6.
    Berlinger NT, Koutroupas S, Adams G, Maisel R (1980) Patterns of involvement of the temporal bone in metastatic and systemic malignancy. Laryngoscope 90(4):619–627CrossRefGoogle Scholar
  7. 7.
    Chang KH, Kim DK, Jun BC, Park YS (2009) Temporal bone myeloid sarcoma. Clin Exp Otorhinolaryngol 2(4):198–202CrossRefGoogle Scholar
  8. 8.
    Noh BW, Park SW, Chun JE, Kim JH, Kim HJ, Lim MK (2009) Granulocytic sarcoma in the head and neck: CT and MR imaging findings. Clin Exp Otorhinolaryngol 2(2):66–71CrossRefGoogle Scholar
  9. 9.
    Yamauchi K, Yasuda M (2002) Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature. Cancer 94(6):1739–1746CrossRefGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2015

Authors and Affiliations

  • Bee See Goh
    • 1
    • 2
    Email author
  • Chian Ling Tang
    • 1
  • Geok Chin Tan
    • 3
  1. 1.Department of Otorhinolaryngology-Head and Neck SurgeryUniversiti Kebangsaan MalaysiaWilayah Persekutuan Kuala LumpurMalaysia
  2. 2.Institute of Ear, Hearing and Speech (Institute-HEARS)Universiti Kebangsaan MalaysiaKuala LumpurMalaysia
  3. 3.Department of PathologyUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia

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