Allergic Rhinitis in Children: A Randomized Clinical Trial Targeted at Symptoms

  • Nicola Mansi
  • Gabriele D’Agostino
  • Antonella Silvia Scirè
  • Giada Morpurgo
  • Dario Gregori
  • Achal Gulati
  • Valerio Damiani
Original Article
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Abstract

Allergic rhinitis (AR) underlies many symptoms and complications which severely affect children’s quality of life. This two-arm study aimed at evaluate the efficacy and safety of the medical device Narivent® versus topical corticosteroids in the symptomatic management of allergic rhinitis in paediatric patients. A randomized study was conducted. Forty subjects with a diagnosis of allergic rhinitis were randomized to receive one puff of Narivent® into each nostril twice daily for 30 days (n = 20) or to receive one puff of topical intranasal corticosteroid into each nostril twice daily for 30 days (n = 20). In both treatment arms, severity of major symptoms related to AR, including nasal congestion, rhinorrhoea, sneezing and nasal itching, was assessed subjectively on a 0–100 mm visual analogue scale. Nasal congestion, rhinorrhoea and sneezing improved significantly after 30 days of treatment with Narivent®. Similarly, in topical steroids group severity of all subjective symptoms decreased significantly. Narivent® appears to be efficacious in treating nasal congestion and other major symptoms in children with AR over a 30-day period, showing comparable results to intranasal corticosteroids therapy but with a better safety profile.

Keywords

Intranasal corticosteroids Osmotically-acting medical device Anti-oedematous Anti-inflammatory Allergic rhinitis Children 

Copyright information

© Association of Otolaryngologists of India 2014

Authors and Affiliations

  • Nicola Mansi
    • 1
  • Gabriele D’Agostino
    • 1
  • Antonella Silvia Scirè
    • 2
  • Giada Morpurgo
    • 2
  • Dario Gregori
    • 3
  • Achal Gulati
    • 4
  • Valerio Damiani
    • 5
  1. 1.S.C. di Otorinolaringoiatria della A.O.R.N. Santobono Pausilipon di NapoliNaplesItaly
  2. 2.Zeta Research SrlTriesteItaly
  3. 3.Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular SciencesUniversity of PadovaPaduaItaly
  4. 4.E.N.T. DepartmentMaulana Azad Medical College and LNNew DelhiIndia
  5. 5.ENT Department San Giovanni Addolorata HospitalRomeItaly

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