Impact of Clinical and Histo-Pathological Prognostic Factors on T1-2N0-1 Oral Tongue Carcinoma

  • Pichit Sittitrai
  • Chonticha Srivanitchapoom
  • Pongsak Mahanupab
  • Thienchai Pattarasakulchai
  • Rak Tananuvat
  • Warat Unejanum
Original Article


To determine predictive factors which affect local and regional recurrence of T1-2N0-1M0 oral tongue carcinoma (OTC). Records of 42 patients with T1-2N0-1 M0 OTC were reviewed. The clinical characteristics, histo-pathological data, disease recurrence and survival rate were analyzed. Descriptive statistics and Kaplan–Meier survival analysis were used. The median follow up was 38 months. The 2-year overall survival and disease-free survival rates were 85.7 and 55.6 % respectively. At the 2 year analysis, there were surgical margin <5 mm (p value = 0.01), tumor thickness >7 mm (p value = 0.03), perivascular and perilymphatic invasion (p value = 0.01) affected on local recurrence and perivascular and perilymphatic invasion were also predictors for regional recurrence (p value = 0.04). The surgical margin status, tumor thickness, perivascular and perilymphatic invasion represented significant predictive factors for local recurrent OTC. Postoperative adjuvant therapy should be considered in these groups.


Tongue carcinoma Early stage Clinical prognostic factor Histo-pathological prognostic factor 


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Copyright information

© Association of Otolaryngologists of India 2012

Authors and Affiliations

  • Pichit Sittitrai
    • 1
  • Chonticha Srivanitchapoom
    • 1
  • Pongsak Mahanupab
    • 2
  • Thienchai Pattarasakulchai
    • 1
  • Rak Tananuvat
    • 1
  • Warat Unejanum
    • 1
  1. 1.Head and Neck Surgery Unit, Department of OtolaryngologyFaculty of Medicine, Chiang Mai UniversityChiang MaiThailand
  2. 2.Department of PathologyFaculty of Medicine, Chiang Mai UniversityChiang MaiThailand

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