Intratympanic Dexamethasone on Cochlear Blood Flow in Guinea Pigs

  • Rayleigh Ping-Ying Chiang
  • Ching-Ying Yeh
  • Yuh-Chyun Chiang
  • Kai-Nan Lin
Invited Article


To determine the effect of intratympanically delivered dexamethasone on cochlear blood flow. 29 white Hartly guinea pigs were divided into 2 groups. By laser Doppler flowmeter, baseline data were recorded in the first 15–20 min, followed by 20 min’ recording after applying dexamethasone or normal saline, with a record of flow every 5 min in 2 groups. Friedman Test was used to test the change of blood flow in these four timing. There were no significant changes of blood flow after injecting dexamethasone (p = .18 > .05) and normal saline (p = .93 > .05). The effects of dexamethasone on cochlear blood flow were variable and not significant. The following research would be designed under pathological conditions, such as cochlear ischemia, to show the possible mechanism of dexamethasone for specific inner ear disease. Level of evidence: 3a (SR of case–control studies).


Steroids Microcirculation Round window Laser Doppler flowmeter 


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Copyright information

© Association of Otolaryngologists of India 2012

Authors and Affiliations

  • Rayleigh Ping-Ying Chiang
    • 1
    • 2
    • 3
  • Ching-Ying Yeh
    • 4
  • Yuh-Chyun Chiang
    • 5
    • 6
  • Kai-Nan Lin
    • 7
    • 8
  1. 1.Department of Otolaryngology Head and Neck Surgery, School of MedicineFu Jen Catholic UniversityTaipeiTaiwan
  2. 2.Department of Otolaryngology Head and Neck SurgeryShin Kong Wu Ho-Su Memorial HospitalTaipeiTaiwan
  3. 3.Sleep Technology Special Interest Group, Center of Innovation and Synergy for Intelligent Home TechnologyNational Taiwan UniversityTaipeiTaiwan
  4. 4.School of Public HealthTaipei Medical University TaiwanTaipei CityTaiwan, ROC
  5. 5.Department of OtolaryngologyTaiwan Adventist HospitalTaipeiTaiwan
  6. 6.Department of Otolaryngology, School of MedicineTaipei Medical UniversityTaipeiTaiwan
  7. 7.Department of Otolaryngology Head and Neck SurgeryCardinal Tien HospitalHsintien, Taipei CountyTaiwan
  8. 8.Department of Otolaryngology Head and Neck SurgeryNational Taiwan University HospitalHsintien, Taipei CountyTaiwan

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