Advertisement

Oxymetazoline plus dexpanthenol in nasal congestion

  • Mohan V. JagadeEmail author
  • Deepak G. Langade
  • Rupesh R. Pophale
  • Arun Prabhu
Short Communication

Abstract

Aims

To compare the efficacy and tolerability of Oxymetazoline 0.05 % plus Dexpanthanol 5% versus Xylometazoline 0.1 % nasal drops in patients with nasal congestion due to allergic rhinitis and following nasal surgery.

Methods

An investigator-blind, randomized, controlled, phase IV clinical trial conducted in 100 patients with acute allergic rhinitis or patients post-nasal surgery. Patients received either Oxymetazoline 0.05% with Dexpanthanol 5% (OD) or Xylometazoline 0.1% (XO) nasal drops.

Results

Relief from nasal congestion was significantly better in the OD group then in the XO group (mean nasal scores 1.24 vs 1.86). Significantly more improvement in sneezing and decrease in nasal discharge was seen in the OD group than the XO group. Nasal irritation in the OD group was significantly less as compared to XO group (0.38 v/s 1.12 on second day and 0.10 vs 0.36 on the fourth day). The recovery time for OD group was 1.08 hours, which was significantly (46 min) lesser than that of the XO group. Rebound congestion was significantly less in OD as compared to XO group (6.25% vs 82.98%). 93.75% of the physicians in the OD group and 51.28% in XO group reported response to therapy as good to excellent. 95.83% patients in the OD group and only 52.91% patients in the XO group rated tolerability to therapy as good to excellent.

Conclusion

Oxymetazoline and dexpanthenol combination has a better efficacy, shorter recovery time, causes lesser rebound congestion and has better tolerability than xylometazoline.

Key words

Oxymetazoline dexpanthenol xylometazoline rebound congestion 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kehrl W, Sonnemann U, Dethlefsen U. Advance in therapy of acute rhinitis-comparison of efficacy and safety of xylometazoline in combination xylometazolinedexpanthenol in patients with acute rhinitis. Laryngorhinootologie. 2003 Apr;82(4):266–71.PubMedCrossRefGoogle Scholar
  2. 2.
    Kehrl W, Sonnemann U. Improving wound healing after nose surgery by combined administration of xylometazoline and dexpanthenol. Laryngorhinootologie. 2000 Mar; 79(3):151–4.PubMedCrossRefGoogle Scholar
  3. 3.
    Hosemann W, Wigand ME, Gode U, Langer F, Dunker I. Normal wound healing of the paranasal sinuses: clinical and experimental investigations. Eur Arch Otorhinolaryngol. 1991;248(7):390–4.PubMedCrossRefGoogle Scholar
  4. 4.
    Klocker N, Verse T, Rudolph P. The protective effect of dexpanthenol in nasal sprays. First results of cytotoxic and ciliary-toxic studies in vitro. Laryngorhinootologie. 2003 Mar;82(3):177–82.PubMedCrossRefGoogle Scholar
  5. 5.
    Klocker N, Rudolph P, Verse T. Evaluation of protective and therapeutic effects of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. Am J Rhinol. 2004 Sep-Oct;18(5):315–20PubMedGoogle Scholar
  6. 6.
    Westfall TC, Westfall DP. Adrenergic agonists and antagonists. In: Goodman & Gilman’s. The Pharmacological Basis Of Therapeutics. Eleventh Edition. Page 262Google Scholar
  7. 7.
    Tuettenberg A; Koelsch S; Knop J; Jonuleit H. Oxymetazoline modulates proinflammatory cytokines and the T-cell stimulatory capacity of dendritic cells. Exp Dermatol. 2007; 16(3):171–8 (ISSN: 0906-6705)PubMedCrossRefGoogle Scholar
  8. 8.
    Dorn M; Hofmann W; Knick E. Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis. HNO. 2003; 51(10):794–9PubMedCrossRefGoogle Scholar
  9. 9.
    Westerveld GJ; Scheeren RA; Dekker I; Griffioen DH; Voss HP; Bast A. Antioxidant actions of oxymethazoline and xylomethazoline. Eur J Pharmacol. 1995; 291(1):27–31PubMedCrossRefGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2008

Authors and Affiliations

  • Mohan V. Jagade
    • 1
    Email author
  • Deepak G. Langade
    • 2
  • Rupesh R. Pophale
    • 3
  • Arun Prabhu
    • 4
  1. 1.Dept of ENTGrant Medical College & Sir J.J. Group of HospitalsMumbaiIndia
  2. 2.Dept of PharmacologyGrant Medical College & Sir J.J. Group of HospitalsMumbaiIndia
  3. 3.Dept of PharmacologyGrant Medical College & Sir J.J. Group of HospitalsMumbaiIndia
  4. 4.Dept of ENTGrant Medical College & Sir J.J. Group of HospitalsMumbaiIndia

Personalised recommendations