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Theory in Biosciences

, Volume 130, Issue 1, pp 55–69 | Cite as

A model-based strategy to investigate the role of microRNA regulation in cancer signalling networks

  • Svetoslav Nikolov
  • Julio Vera
  • Ulf Schmitz
  • Olaf Wolkenhauer
Original Paper

Abstract

In this paper we present and discuss a model-based approach to link miRNA translational control with cell signalling networks. MicroRNAs are small regulatory RNAs that are able to regulate the activity and the stability of specific messenger RNA and have been implicated in tumour progression due to their ability to translationally regulate critical oncogenes and tumour suppressors. In our approach, data on protein–protein interactions and miRNA regulation, obtained from bioinformatics databases, are integrated with quantitative experimental data using mathematical modelling. Predictive computational simulations and qualitative (bifurcation) analyses of those mathematical models are employed to further support the investigation of such multifactorial networks in the context of cancer progression. We illustrate our approach with the C-Myc/E2F signalling network, involved in the progression of several tumour subtypes, including colorectal cancer.

Keywords

miRNA Cancer networks Systems biology Bioinformatics Translational regulation 

Notes

Acknowledgments

This work was supported by DAAD-Bulgarian National Science Fund project DO02-23/05.3.2009. J.V. is funded by the German Federal Ministry of Education and Research (BMBF) as part of the project CALSYS-FORSYS under contract 0315264 (www.sbi.uni-rostock.de/calsys). O.W. was supported by the Helmholtz Foundation as part of the Systems Biology Network.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Svetoslav Nikolov
    • 1
  • Julio Vera
    • 2
  • Ulf Schmitz
    • 2
  • Olaf Wolkenhauer
    • 2
  1. 1.Institute of MechanicsBulgarian Academy of SciencesSofiaBulgaria
  2. 2.Department of Systems Biology & BioinformaticsUniversity of RostockRostockGermany

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