Graft patency study in off-pump coronary artery bypass surgery

  • Arani Raghavendra Rao Raghuram
  • Krishnaswamy Subramanyan
  • Subbiah Sivakumaran
  • Purushothaman Chandrasekar
  • Subramanian Harikrishnan
  • Govindarajan Arunkumar
Original Article

Abstract

Purpose

Off-pump coronary artery bypass (OPCAB) is known to reduce operative morbidity, intensive care and hospital stay and blood usage. Recent reports have highlighted the poor results after off-pump coronary artery bypass. So, we decided to look at the angiographic patency of our patients at the end of 3 months.

Methods

Out of 265 patients who underwent isolated primary coronary artery bypass graft surgery (CABG) in a 2-year period at our institution, 118 are the subjects for this study. The anticoagulation and antiplatelet protocols are explained in detail. These patients underwent computerised tomography (CT) of coronary arteries to evaluate the graft patency. The results were studied by a competent radiologist with advanced Windows 4.7 workstation.

Results

There were 118 patients with a total of 380 anastomoses for evaluation. Twenty patients (16.95%) had some of their grafts blocked. Out of a total of 380 anastomoses, 24 were found to be blocked (6.3%). Left internal mammary artery had 98.3% patency. Left radial artery showed a patency rate of 96%. Saphenous vein grafts had a patency rate of 91.2%. The anterior and inferior territory grafts were patent in greater than 95% of patients, whereas lateral wall grafts were patent in 86% of patients. There was no mortality in this series. One patient reported angina. Fifty-eight patients had a treadmill test and 51 were negative and 7 had positive results for inducible ischemia.

Conclusions

OPCAB is a safe technique with acceptable clinical outcome and angiographic patency in experienced hands.

Keywords

Coronary artery bypass grafting Left internal mammary artery Radial artery 

Notes

Acknowledgements

We would like to thank Mr. Pavithran, Ms. Ambika and Ms. Divya for their secretarial assistance in tabulation of results and typing works.

Funding

No funding from any agency has been received for this study.

Compliance with ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institution and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all the patients before the procedure.

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Wijeysundera DN, Beattie WS, Djaiani G, et al. Off pump coronary artery surgery for reducing mortality and morbidity – meta analysis of randomised and observational studies. J Am Coll Cardiol. 2005; 46:872–82.Google Scholar
  2. 2.
    Ascione R, Lloyd CT, Underwood MJ, Lotto AA, Pitsis AA, Angelini GD. Economic outcome of off-pump coronary artery bypass surgery. A prospective randomised study. Ann Thorac Surg. 1999;68:2237–42.Google Scholar
  3. 3.
    Puskas JD, Williams WH, Mahoney EM, et al. Off-pump vs conventional coronary artery bypass grafting: early and 1-year graft patency, cost and quality- of- life outcomes: a randomised trial. JAMA. 2004;291;1841–9.Google Scholar
  4. 4.
    Nathoe HM, van Dijk D, Jansen EW, et al. A comparison of on-pump and off-pump coronary bypass surgery in low risk patients. N Engl J Med. 2003;348:394–402.Google Scholar
  5. 5.
    Cleveland JC Jr, Shroyer AL, Chen AY, Peterson E, Grover FL. Off-pump coronary artery bypass grafting decreases risk adjusted mortality and morbidity. Ann Thorac Surg. 2001;72:1282–8.Google Scholar
  6. 6.
    Keogh BE, Kinsman R. Fifth national adult cardiac surgical database report for 2003. Henley on Thames, United Kingdom: Dendrite clinical systems; 2004.Google Scholar
  7. 7.
    Sajja LR. The journey of surgery for coronary artery disease in India: Adoption,Customization and Innovation. Sadasivam Oration. Ind J Thorac Cardiovasc Surg. 2014;30:116–128.Google Scholar
  8. 8.
    Sajja LR, Mannan G, Sompally S. Extrafascially harvested radial artery graft in CABG: technique of harvest, complications, and mid-term angiographic patency. J Card Surg. 2005;20:440–448.Google Scholar
  9. 9.
    Widimsky P, Straka Z, Stros P, et al. One-Year coronary bypass graft patency – A randomised comparison between off-pump and on-pump surgery Angiographic results of the PRAGUE 4 Trial. Circulation. 2004;110:3418–3423.Google Scholar
  10. 10.
    Lamy A, Devereaux PJ, Prabhakaran D, et al. Off-pump or on-pump coronary- artery bypass grafting at 30 days. N Engl J Med. 2012;366:1489–97.Google Scholar
  11. 11.
    Lamy A, Devereaux PJ, Prabhakaran D, et al. Five-year outcomes after off-pump or on-pump coronary-artery bypass grafting. N Engl J Med. 2016;375:2359–68.Google Scholar
  12. 12.
    Hattler B, Messenger JC, Shroyer AL, et al. Off-pump coronary artery bypass surgery is associated with worse arterial and saphenous vein graft patency and less effective revascularisation. Results from the Veterans Affairs Randomised On/Off Bypass (ROOBY) Trial. Circulation. 2012;125:2827–2835.Google Scholar
  13. 13.
    Houlind K, Fenger-Gron M, Holme SJ, et al. Graft Patency after off-pump coronary artery bypass surgery is inferior even with identical heparinisation protocols: Results from Danish on-pump versus off-pump randomisation study (DOORS). J Thorac Cardiovasc Surg. 2014;148:1812–9.Google Scholar
  14. 14.
    Angelini GD, Culliford L, Smith DK, et al. Effect of on- and off-pump coronary artery surgery on graft patency, survival and health related quality of life: Long-term follow-up of 2 randomized controlled trials. J Thorac Cardiovasc Surg. 2009;137:295–303.Google Scholar
  15. 15.
    Diegler A, Borgermann J, Kappert U, et al. Off-Pump versus On-Pump Coronary-Artery Bypass Grafting in Elderly Patients N Engl J Med. 2013;368:1189–98.Google Scholar
  16. 16.
    Nicolini F, Fortuna D, Contini GA, et al. Comparison between off and on-pump coronary artery bypass grafting: long-term results of a real world registry. Eur J Cardiothorac Surg. 2016;50:528–535.Google Scholar
  17. 17.
    Fukui T, Tabata M, Manabe S, Shimokawa T, Takanashi S. Graft selection and one-year patency rates in patients undergoing coronary artery bypass grafting. Ann Thorac Surg. 2010;89:1901–5.Google Scholar
  18. 18.
    Goldman S, Zadina K, Moritz T, et al. Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery. Results from a Department of Veteran affairs cooperative study. J Am Coll Cardiol. 2004;44:2149–56.Google Scholar
  19. 19.
    Yoo KJ, Choi D, Choi BW, Lim SH, Chang BC. The comparison of graft patency after coronary artery bypass grafting using coronary angiography and multi-slice computed tomography. Eur J Cardiothorac Surg. 2003;24:86–91.Google Scholar
  20. 20.
    Yammamoto M, Kimura F, Niinami H, Suda Y, Ueno E, Takeuchi Y. Noninvasive assessment of off-pump coronary artery bypass surgery by 16-channel multidetector-row computed tomography. Ann Thorac Surg. 2006;81:820–7.Google Scholar
  21. 21.
    Bassri H, Salari F, Noohi F, et al. Evaluation of early graft patency after coronary artery bypass graft surgery using multislice computed tomography angiography. BMC Cardiovasc Disord. 2009;9:53.Google Scholar

Copyright information

© Indian Association of Cardiovascular-Thoracic Surgeons 2017

Authors and Affiliations

  • Arani Raghavendra Rao Raghuram
    • 1
    • 2
  • Krishnaswamy Subramanyan
    • 1
  • Subbiah Sivakumaran
    • 1
  • Purushothaman Chandrasekar
    • 1
  • Subramanian Harikrishnan
    • 1
  • Govindarajan Arunkumar
    • 1
  1. 1.Institute of Cardiac SciencesSRM Institutes of Medical Sciences (SIMS)ChennaiIndia
  2. 2.ChennaiIndia

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