, Volume 24, Issue 3, pp 381–391 | Cite as

What the Mother Gives…

  • Beena PillaiEmail author
General Article


Life starts from a single cell formed by the union of the sperm and egg. Genes inherited from the parents influence many features of the offspring — from physical appearance and disease susceptibility to more complex traits like behavior and cognitive abilities. Inherited RNA, both protein-coding and non-coding, transferred from the parents to the zygote can modify the information in the genome of the offspring during the early stages of development. Emerging evidence supports the possibility that non-coding regulatory RNA inherited from the egg and sperm may shape the offsprings’ genome. The RNAs may mark positions in the genome that need to be activated at a precise time during development. They may also demarcate genomic landmarks like telomeres and centromeres. Differences in the type and amount of inherited RNA can result in inter-individual variability. By holding together distant regions of the genome, they may shape the 3D genome organization. These direct regulatory roles during the early stages of development may have long term consequences on the expression of genes and eventually on the traits of the offspring.


Epigenetic inheritance methylation histones miRNA maternal genes 


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Suggested Reading

  1. [1]
    M A Sarangdhar, D Chaubey, N Srikakulam, B Pillai, Parentally inherited long non-coding RNA cyrano is involved in zebrafish neurodevelopment, Nucleic Acids Res., 12;46(18), pp.9726–9735, October 2018.CrossRefGoogle Scholar
  2. [2]
    M A Sarangdhar, D Chaubey, A Bhatt, M Kumar, S Ranjan, B Pillai, A Novel Long Non-coding RNA, durga Modulates Dendrite Density and Expression of kalirin in Zebrafish, Front Mol Neurosci., 10;10:95, April 2017.Google Scholar
  3. [3]
    Q Chen, W Yan, E Duan, Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications, Nat Rev Genet., 17(12):, pp.733–743, December 2016.CrossRefGoogle Scholar
  4. [4]
    J Brennecke, C D Malone, A A Aravin, R Sachidanandam, A Stark, G J Hannon, An epigenetic role for maternally inherited piRNAs in transposon silencing, Science, 28;322(5906), pp.1387–92, November 2008.CrossRefGoogle Scholar
  5. [5]
    R Liebers, M Rassoulzadegan, F Lyko, Epigenetic Regulation by Heritable RNA, PLoS Genet., 10(4): e1004296, April 2014.CrossRefGoogle Scholar
  6. [6]
    M V Koerner, F M Pauler, R Huang, and D P Barlow, The function of noncoding RNAs in genomic imprinting, Development, 136, pp.1771–1783, 2009.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.CSIR-Institute of Genomics and Integrative Biology South CampusNew DelhiIndia

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