, Volume 24, Issue 3, pp 327–338 | Cite as

Protein Structure

  • Lalitha GuruprasadEmail author
General Article


Proteins are essential biological macromolecules associated with a variety of physiological functions. In this article, the composition, conformational features, and general principles that govern protein folding are presented.


Proteins amino acids α-helix β-strand protein folding tertiary structure 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  1. [1]
    L Pauling, R B Corey, Configurations of Polypeptide Chains With Favored Orientations Around Single Bonds. Two New Pleated Sheets, Proc. Natl. Acad. Sci. USA, Vol.37, No.11, pp.729–740, 1951.CrossRefGoogle Scholar
  2. [2]
    L Pauling, R B Corey, H R Branson, The Structure of Proteins: Two Hydrogen-bonded Helical Configurations of the Polypeptide Chain, Proc. Natl. Acad. Sci. USA, Vol.37 No.4, pp.205–211, 1951.CrossRefGoogle Scholar
  3. [3]
    G N Ramachandran, C Ramakrishnan, V Sasisekharan, Stereochemistry of Polypeptide Chain Configurations, J. Mol. Biol., Vol.7, pp.95–99, 1963.CrossRefGoogle Scholar
  4. [4]
    C Levinthal, How to Fold Graciously, Mössbaun Spectroscopy in Biological Systems Proceedings, Univ. of Illinois Bulletin, Vol.67, No.41, pp.22–24, 1969.Google Scholar
  5. [5]
    C B Anfinsen, Principles that Govern the Folding of Protein Chains, Science, Vol.181, No.4096, pp.223–230, 1973.CrossRefGoogle Scholar
  6. [6]
    F M Richards, The Interpretation of Protein Structures: Total Volume, Group Volume Distributions and Packing Density, J. of Mol. Biol., Vol.82, No.1, pp.1–14, 1974.CrossRefGoogle Scholar
  7. [7]
    R Dunbrack Jr, M Karplus, Conformational Analysis of the Backbone-Dependent Rotamer Preferences of Protein Sidechains, Natu. Struc. Biol., Vol.1, No.5, pp.334–340, 1994.CrossRefGoogle Scholar
  8. [8]
    D E Koshland Jr, Correlation of Structure and Function in Enzymatic Reaction, Science, Vol.142, No. 3599, pp.1533–1541, 1963.CrossRefGoogle Scholar
  9. [9]
    Jeremy M Berg, Lubert Stryer, John L Tymoczko, Gregory J Gatto, Biochemistry, (8th Edition), Publishers: WH Freeman, April 2015.Google Scholar

Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.School of ChemistryUniversity of HyderabadHyderabadIndia

Personalised recommendations