This is the story of a determined Indian who strived very hard and achieved greatness. He went to Harvard Medical School with very little money, braved many grave hardships and eventually fulfilled his ambitions to a large extent. Yellapragada SubbaRow did research in Harvard Medical School in biological chemistry and directed research at Lederle Laboratories, a pharmaceutical giant near New York. He played an important part in several historic and extraordinary discoveries made in biological chemistry and medicine during 1924–1948. Some of the important ones are phosphocreatine, adenosine triphosphate, vitamin B9, antifolate cancer drugs, filaricides and antibiotics. He made many personal sacrifices to accomplish what he wanted to. He received little recognition during his lifetime, but is now hailed as one of the most eminent medical minds of the century.