Journal of Genetics

, 98:95 | Cite as

Language impairment in primary progressive aphasia and other neurodegenerative diseases

  • D. R. Rahul
  • R. Joseph PonniahEmail author
Review Article


Primary progressive aphasia (PPA) is a progressive neurodegenerative disease that disrupts the language capacity of an individual by selectively affecting the language network of brain. Although aphasic literature is replete with reports of brain damage responsible for various types of PPA, it does not provide a comprehensive understanding of whether PPA is an independent pathological condition or an atypical syndrome of neurodegenerative diseases (NDD). To address this ambiguity, we provide a detailed description of PPA, its variants and their brain anatomy. Subsequently, we unravel the relationship between PPA and NDDs like Alzheimer’s, Parkinson’s and Dyslexia. To substantiate the relationship further, we also provide a brief account of their genetic aetiology. In the final section, we offer an exhaustive approach towards the treatment of PPA by combining the existing language therapies with clinical and pharmacological interventions.


primary progressive aphasia aphasia Alzheimer Parkinson dyslexia GRN gene 


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© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.National Institute of TechnologyTiruchirappalliIndia

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