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Journal of Genetics

, 98:59 | Cite as

Genetic variant rs10937405 of TP63 and susceptibility to lung cancer risk in north Indian population

  • GH. Rasool Bhat
  • Amrita Bhat
  • Sonali Verma
  • Itty Sethi
  • Ruchi Shah
  • Varun Sharma
  • S. Minerva
  • Divya Bakshi
  • Bhanu Sharma
  • Sandeep Koul
  • Deepak Abrol
  • Audesh Bhat
  • Rakesh KumarEmail author
Research Article
  • 58 Downloads

Abstract

Several studies including genomewide association studies (GWASs) in diverse ethnic populations have reported a significant association of genetic variant rs10937405 of TP63 with nonsmall cell lung cancer (NSCLC). However, no data are available from any Indian population on the association of this variant with NSCLC. Using TaqMan genotyping chemistry, we conducted a case–control study involving 190 NSCLC cases and 400 ethnic, age-matched controls to explore the association of rs10937405 genetic variant with NSCLC in patients from north India. Our data support that the rs10937405 variant is also significantly associated with the NSCLC and is a risk factor in the north Indian populations to develop NSCLC. However, unlike most other studies, the wild-type allele T appears to be the risk allele, as its frequency was significantly higher in the cases than controls (0.439 in cases versus 0.383 in controls. OR = 1.95 (1.23–3.09 at 95% CI); P value (adjusted) = 0.004). Genetic association was also observed by applying different genetic models. The present study provides important information of the genetic aetiology of NSCLC and strengthens GWAS findings, highlighting the role of TP63 in lung cancer risk.

Keywords

TaqMan genotyping chemistry nonsmall cell lung cancer north India 

Notes

Acknowledgements

RK and GRB acknowledge Department of Science & Technology, Government of India project (DST/SSTP/J&K/459) for financial assistance.

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  • GH. Rasool Bhat
    • 1
  • Amrita Bhat
    • 1
  • Sonali Verma
    • 1
  • Itty Sethi
    • 2
  • Ruchi Shah
    • 2
  • Varun Sharma
    • 2
  • S. Minerva
    • 1
  • Divya Bakshi
    • 1
  • Bhanu Sharma
    • 1
  • Sandeep Koul
    • 3
  • Deepak Abrol
    • 4
  • Audesh Bhat
    • 5
  • Rakesh Kumar
    • 1
    Email author
  1. 1.Cancer Genetics Research Group, School of BiotechnologyShri Mata Vaishno Devi UniversityKatraIndia
  2. 2.Human Genetics Research Group, School of BiotechnologyShri Mata Vaishno Devi UniversityKatraIndia
  3. 3.Department of Surgical OncologyShri Mata Vaishno Devi Narayana Super Speciality HospitalKatraIndia
  4. 4.Department of RadiotherapyGovernment Medical College JammuJammuIndia
  5. 5.Center of Molecular BiologyCentral University of JammuJammuIndia

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