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Journal of Genetics

, 98:20 | Cite as

Genomewide association study for C-reactive protein in Indians replicates known associations of common variants

  • Gauri Prasad
  • Anil K. Giri
  • Indico Consortium
  • Analabha Basu
  • Nikhil TandonEmail author
  • Dwaipayan BharadwajEmail author
Research Article

Abstract

Elevated C-reactive protein (CRP) serves as an independent biomarker for acute and chronic inflammation, and is also associated with metabolic diseases. Genomewide loci regulating CRP level in Indian population, a high-risk group for metabolic illness, is unexplored. Therefore, we aimed to discover common polymorphisms associated with plasma CRP level in 4493 Indians of Indo-European origin using genomewide association study. Genomewide strong associations of two known intronic variants in hepatocyte nuclear factor-\(1\upalpha \) gene (HNF1A) were identified among Indian subjects. We also detected prior associations of several variants in/near metabolic and inflammatory process genes: APOC1, LEPR, CRP, HNF4A, IL6R and APOE with modest associations. This study confirms that Indians from Indo-European origin display similar core universal genetic factors for CRP levels.

Keywords

C-reactive protein genomewide association study Indians metabolic diseases 

Notes

Acknowledgements

The authors are thankful to all the study participants and the members of INdian DIabetes COnsortium (INDICO) for their support in generation of data. This study was supported by grants provided by the Council of Scientific and Industrial Research (CSIR), Government of India through Centre for Cardiovascular and Metabolic Disease Research (CARDIOMED) project (Grant no. BSC0122-(13)). This study was also partially funded by the Department of Science and Technology, Government of India through PURSE II CDST/SR/PURSE PHASE II/11. GP and AKG acknowledge University Grants Commission (UGC), Government of India for Senior Research Fellowship.

Supplementary material

12041_2019_1065_MOESM1_ESM.docx (59 kb)
Supplementary material 1 (docx 58 KB)

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Copyright information

© Indian Academy of Sciences 2019

Authors and Affiliations

  1. 1.Genomics and Molecular Medicine UnitCSIR-Institute of Genomics and Integrative BiologyNew Delhi India
  2. 2.Academy of Scientific and Innovative ResearchCSIR-Institute of Genomics and Integrative Biology CampusNew DelhiIndia
  3. 3.National Institute of Biomedical GenomicsNetaji Subhas Sanatorium (Tuberculosis Hospital)KalyaniIndia
  4. 4.Department of Endocrinology and MetabolismAll India Institute of Medical SciencesNew DelhiIndia
  5. 5.Systems Genomics Laboratory, School of BiotechnologyJawaharlal Nehru UniversityNew DelhiIndia

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