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Journal of Genetics

, Volume 97, Issue 4, pp 987–994 | Cite as

Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Han population

  • Huan Zhang
  • Xingbo Mo
  • Zhengyuan Zhou
  • Zhengbao Zhu
  • Xinfeng HuangFu
  • Tan Xu
  • Aili Wang
  • Zhirong Guo
  • Yonghong ZhangEmail author
Research Article
  • 46 Downloads

Abstract

Obesity is the third most risk factors of death in the middle-income and high-income countries. Whether DNA polymorphisms in CORIN and NPPA genes were associated with obesity, and if these associations could be modified by smoking in the Chinese Han population were unknown, hence a group of 1507 participants were recruited and genotyped for 12 tag single-nucleotide polymorphisms (SNPs) of CORIN and NPPA genes. Regression models were used to test the associations of SNPs with obesity. The potential SNP–smoking interactions were detected in regression models. NPPA SNPs rs5063 and rs198358 were associated with the body mass index (BMI) (\(P=0.0053\) and 0.0037, respectively). Rs198358 was associated with obesity in both univariate- and multivariable-adjusted analyses (\(P=0.0138\) and 0.0173, respectively). Rs5063 was associated with central obesity in both univariate- and multivariable-adjusted analyses (\(P=0.0454\) and 0.0361, respectively). Significant interactions between cigarette smoking and rs5063 and rs198358 were detected (\(P=0.0019\) and 0.0006, respectively). In subgroup analyses, rs5063 and rs198358 were associated with central obesity in smokers (\(P=0.0081\) and 0.0037, respectively). The results of our study demonstrated that the effect of NPPA SNPs rs5063 and rs198358 on central obesity might be modified by smoking in the Chinese Han population. Further studies are needed to confirm the associations and elucidate the underlying mechanisms.

Keywords

corin atrial-natriuretic peptides obesity genetic association smoking 

Notes

Acknowledgements

This study was supported by the National Natural Science Foundation of China (81773508, 81302499 and 81320108026), the Key Research Project (Social Development Plan) of Jiangsu Province (BE2016667), Project funded by China Postdoctoral Science Foundation (2014T70547, 2013M530269 and 2014M551649), the Startup Fund from Soochow University (Q413900313 and Q413900412), and a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions.

References

  1. Barrett J. C., Fry B., Maller J. and Daly M. J. 2005 Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263–265.CrossRefGoogle Scholar
  2. Bazzano L. A., Gu D., Reynolds K., Wu X., Chen C. S., Duan X. et al. 2007 Alcohol consumption and risk for stroke among Chinese men. Ann. Neurol. 62, 569–578.CrossRefGoogle Scholar
  3. Carney R. M. and Goldberg A. P. 1984 Weight gain after cessation of cigarette smoking. A possible role for adipose-tissue lipoprotein lipase. N. Engl. J. Med. 310, 614–616.CrossRefGoogle Scholar
  4. Chan J. C., Knudson O., Wu F., Morser J., Dole W. P. and Wu Q. 2005 Hypertension in mice lacking the proatrial natriuretic peptide convertase corin. Proc. Natl. Acad. Sci. USA 102, 785–790.CrossRefGoogle Scholar
  5. Chen X., Li S., Yang Y., Yang X., Liu Y., Hu W. et al. 2012 Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease. J. Thromb. Haemost. 10, 1508–1514.CrossRefGoogle Scholar
  6. Chiolero A., Jacot-Sadowski I., Faeh D., Paccaud F. and Cornuz J. 2007 Association of cigarettes smoked daily with obesity in a general adult population. Obesity (Silver Spring) 15, 1311–1318.CrossRefGoogle Scholar
  7. Dong N., Chen S., Yang J., He L., Liu P., Zheng D. et al. 2010 Plasma soluble corin in patients with heart failure. Circ. Heart Fail. 3, 207–211.CrossRefGoogle Scholar
  8. Dong N., Fang C., Jiang Y., Zhou T., Liu M., Zhou J. et al. 2013 Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment. J. Biol. Chem. 288, 7867–7874.CrossRefGoogle Scholar
  9. Dries D. L., Victor R. G., Rame J. E., Cooper R. S., Wu X., Zhu X. et al. 2005 Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. Circulation 112, 2403–2410.CrossRefGoogle Scholar
  10. Enshell-Seijffers D., Lindon C. and Morgan B. A. 2008 The serine protease Corin is a novel modifier of the Agouti pathway. Development 135, 217–225.CrossRefGoogle Scholar
  11. Fesinmeyer M. D., North K. E., Lim U., Buzkova P., Crawford D. C., Haessler J. et al. 2013 Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. BMC Med. Genet. 14, 6.CrossRefGoogle Scholar
  12. He J., Reynolds K., Chen J., Chen C. S., Wu X., Duan X. et al. 2007 Cigarette smoking and erectile dysfunction among Chinese men without clinical vascular disease. Am. J. Epidemiol. 166, 803–809.CrossRefGoogle Scholar
  13. Hensrud D. D. and Klein S. 2006 Extreme obesity: a new medical crisis in the United States. Mayo Clin. Proc. 81, S5–S10.CrossRefGoogle Scholar
  14. Jin G., Zhu M., Yin R., Shen W., Liu J., Sun J. et al. 2015 Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations. Am. J. Hum. Genet. 96, 832–840.CrossRefGoogle Scholar
  15. Johnson W., Ong K. K., Elks C. E., Wareham N. J., Wong A., Muniz-Terrera G. et al. 2014 Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study. Nutr. Diabetes 4, e136.CrossRefGoogle Scholar
  16. Kelly T., Yang W., Chen C. S., Reynolds K. and He J. 2008 Global burden of obesity in 2005 and projections to 2030. Int. J. Obes. (Lond.) 32, 1431–1437.CrossRefGoogle Scholar
  17. Levin E. R., Gardner D. G. and Samson W. K. 1998 Natriuretic peptides. N. Engl. J. Med. 339, 321–328.CrossRefGoogle Scholar
  18. Lifshitz F. and Lifshitz J. Z. 2014 Globesity: the root causes of the obesity epidemic in the USA and now worldwide. Pediatr. Endocrinol. Rev. 12, 17–34.PubMedGoogle Scholar
  19. Mackay D. F., Gray L. and Pell J. P. 2013 Impact of smoking and smoking cessation on overweight and obesity: Scotland-wide, cross-sectional study on 40,036 participants. BMC Public Health 13, 348.CrossRefGoogle Scholar
  20. Mineur Y. S., Abizaid A., Rao Y., Salas R., DiLeone R. J., Gundisch D. et al. 2011 Nicotine decreases food intake through activation of POMC neurons. Science 332, 1330–1332.CrossRefGoogle Scholar
  21. Narayan K. M., Ali M. K. and Koplan J. P. 2010 Global noncommunicable diseases – where worlds meet. N. Engl. J. Med. 363, 1196–1198.CrossRefGoogle Scholar
  22. Okada Y., Kubo M., Ohmiya H., Takahashi A., Kumasaka N., Hosono N. et al. 2012 Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat. Genet. 44, 302–306.CrossRefGoogle Scholar
  23. Peleg A., Ghanim D., Vered S. and Hasin Y. 2013 Serum corin is reduced and predicts adverse outcome in non-ST-elevation acute coronary syndrome. Eur. Heart J. Acute Cardiovasc. Care 2, 159–165.CrossRefGoogle Scholar
  24. Peng H., Zhang Q., Shen H., Liu Y., Chao X., Tian H. et al. 2015 Association between serum soluble corin and obesity in Chinese adults: a cross-sectional study. Obesity (Silver Spring) 23, 856–861.CrossRefGoogle Scholar
  25. Pierce J. P., Choi W. S., Gilpin E. A., Farkas A. J. and Berry C. C. 1998 Tobacco industry promotion of cigarettes and adolescent smoking. JAMA 279, 511–515.CrossRefGoogle Scholar
  26. Ried J. S., Jeff M. J., Chu A. Y., Bragg-Gresham J. L., van Dongen J., Huffman J. E. et al. 2016 A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat. Commun. 7, 13357.CrossRefGoogle Scholar
  27. Sengenes C., Berlan M., De Glisezinski I., Lafontan M. and Galitzky J. 2000 Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB J. 14, 1345–1351.CrossRefGoogle Scholar
  28. Shungin D., Winkler T. W., Croteau-Chonka D. C., Ferreira T., Locke A. E., Magi R. et al. 2015 New genetic loci link adipose and insulin biology to body fat distribution. Nature 518, 187–196.CrossRefGoogle Scholar
  29. Song W., Wang H. and Wu Q. 2015 Atrial natriuretic peptide in cardiovascular biology and disease (NPPA). Gene 569, 1–6.CrossRefGoogle Scholar
  30. Speliotes E. K., Willer C. J., Berndt S. I., Monda K. L., Thorleifsson G., Jackson A. U. et al. 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937–948.CrossRefGoogle Scholar
  31. Thorleifsson G., Walters G. B., Gudbjartsson D. F., Steinthorsdottir V., Sulem P., Helgadottir A. et al. 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. 41, 18–24.CrossRefGoogle Scholar
  32. Wahl S., Drong A., Lehne B., Loh M., Scott W. R., Kunze S. et al. 2017 Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature 541, 81–86.CrossRefGoogle Scholar
  33. Wang J., Wang Z. and Yu C. 2016 Association of polymorphisms in the atrial natriuretic factor gene with the risk of essential hypertension: a systematic review and meta-analysis. Int. J. Environ. Res. Public Health 13, 458.CrossRefGoogle Scholar
  34. Wang T. J., Larson M. G., Levy D., Benjamin E. J., Leip E. P., Wilson P. W. et al. 2004 Impact of obesity on plasma natriuretic peptide levels. Circulation 109, 594–600.CrossRefGoogle Scholar
  35. Wang T. J., Larson M. G., Keyes M. J., Levy D., Benjamin E. J. and Vasan R. S. 2007 Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals. Circulation 115, 1345–1353.CrossRefGoogle Scholar
  36. Wen W., Cho Y. S., Zheng W., Dorajoo R., Kato N., Qi L. et al. 2012 Meta-analysis identifies common variants associated with body mass index in east Asians. Nat. Genet. 44, 307–311.CrossRefGoogle Scholar
  37. Wen W., Zheng W., Okada Y., Takeuchi F., Tabara Y., Hwang J. Y. et al. 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum. Mol. Genet. 23, 5492–5504.CrossRefGoogle Scholar
  38. Willer C. J., Speliotes E. K., Loos R. J., Li S., Lindgren C. M., Heid I. M. et al. 2009 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25–34.CrossRefGoogle Scholar
  39. Xiao J., Huang J. P., Xu G. F., Chen D. X., Wu G. Y., Zhang M. et al. 2015 Association of alcohol consumption and components of metabolic syndrome among people in rural China. Nutr. Metab. (Lond.) 12, 5.CrossRefGoogle Scholar
  40. Xu F., Yin X. M. and Wang Y. 2007 The association between amount of cigarettes smoked and overweight, central obesity among Chinese adults in Nanjing, China. Asia Pac. J. Clin. Nutr. 16, 240–247.PubMedGoogle Scholar
  41. Yan W., Sheng N., Seto M., Morser J. and Wu Q. 1999 Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. J. Biol. Chem. 274, 14926–14935.CrossRefGoogle Scholar
  42. Yang J., Loos R. J., Powell J. E., Medland S. E., Speliotes E. K., Chasman D. I. et al. 2012 FTO genotype is associated with phenotypic variability of body mass index. Nature 490, 267–272.CrossRefGoogle Scholar
  43. Zaki M. A., El-Banawy Sel D. and El-Gammal H. H. 2012 Plasma soluble corin and N-terminal pro-atrial natriuretic peptide levels in pregnancy induced hypertension. Pregnancy Hypertens. 2, 48–52.CrossRefGoogle Scholar
  44. Zhou B. F. 2002 Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults – study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed. Environ. Sci. 15, 83–96.PubMedGoogle Scholar
  45. Zhou Y. and Wu Q. 2014 Corin in natriuretic peptide processing and hypertension. Curr. Hypertens. Rep. 16, 415.CrossRefGoogle Scholar
  46. Zhou H., Liu W., Zhu J., Liu M., Fang C., Wu Q. et al. 2013 Reduced serum corin levels in patients with osteoporosis. Clin. Chim. Acta. 426, 152–156.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  • Huan Zhang
    • 1
    • 2
  • Xingbo Mo
    • 1
    • 2
    • 3
  • Zhengyuan Zhou
    • 4
  • Zhengbao Zhu
    • 1
    • 2
  • Xinfeng HuangFu
    • 1
    • 2
  • Tan Xu
    • 1
    • 2
  • Aili Wang
    • 1
    • 2
  • Zhirong Guo
    • 1
    • 2
  • Yonghong Zhang
    • 1
    • 2
    Email author
  1. 1.Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesSoochow UniversitySuzhouPeople’s Republic of China
  2. 2.Department of Epidemiology, School of Public HealthMedical College of Soochow UniversitySuzhouPeople’s Republic of China
  3. 3.Center for Genetic Epidemiology and Genomics, School of Public HealthMedical College of Soochow UniversitySuzhouPeople’s Republic of China
  4. 4.Changshu Center of Disease Control and PreventionSuzhouPeople’s Republic of China

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