Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Han population
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Obesity is the third most risk factors of death in the middle-income and high-income countries. Whether DNA polymorphisms in CORIN and NPPA genes were associated with obesity, and if these associations could be modified by smoking in the Chinese Han population were unknown, hence a group of 1507 participants were recruited and genotyped for 12 tag single-nucleotide polymorphisms (SNPs) of CORIN and NPPA genes. Regression models were used to test the associations of SNPs with obesity. The potential SNP–smoking interactions were detected in regression models. NPPA SNPs rs5063 and rs198358 were associated with the body mass index (BMI) (\(P=0.0053\) and 0.0037, respectively). Rs198358 was associated with obesity in both univariate- and multivariable-adjusted analyses (\(P=0.0138\) and 0.0173, respectively). Rs5063 was associated with central obesity in both univariate- and multivariable-adjusted analyses (\(P=0.0454\) and 0.0361, respectively). Significant interactions between cigarette smoking and rs5063 and rs198358 were detected (\(P=0.0019\) and 0.0006, respectively). In subgroup analyses, rs5063 and rs198358 were associated with central obesity in smokers (\(P=0.0081\) and 0.0037, respectively). The results of our study demonstrated that the effect of NPPA SNPs rs5063 and rs198358 on central obesity might be modified by smoking in the Chinese Han population. Further studies are needed to confirm the associations and elucidate the underlying mechanisms.
Keywordscorin atrial-natriuretic peptides obesity genetic association smoking
This study was supported by the National Natural Science Foundation of China (81773508, 81302499 and 81320108026), the Key Research Project (Social Development Plan) of Jiangsu Province (BE2016667), Project funded by China Postdoctoral Science Foundation (2014T70547, 2013M530269 and 2014M551649), the Startup Fund from Soochow University (Q413900313 and Q413900412), and a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions.